Article
Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients
May 1, 2025
Clinical question: Are there alternatives to statins for primary prevention? Background: Statins that lower low-density lipoprotein (LDL) cholesterol are major therapeutics in reducing both primary...
Article
Beta-Blocker Interruption or Continuation after Myocardial Infarction
May 1, 2025
Clinical question: Is the interrupted use of a beta-blocker non-inferior to its continued use in patients with a history of myocardial infarction (MI)? Background: Patients with MI are often started...
Stewardship Prompts to Improve Antibiotic Selection for UTI
May 1, 2025
Clinical question: Can computerized provider order entry (CPOE) prompts reduce the use of empiric extended-spectrum antibiotics in patients with urinary tract infections (UTI)? Background: UTIs...
Article
Effects of Semaglutide on CKD in Patients with Type 2 Diabetes: the FLOW Trial
April 1, 2025
Clinical question: Does treatment with semaglutide in patients with type 2 diabetes and chronic kidney disease (CKD) prevent the progression of CKD or death from kidney and cardiovascular...
Article
High-Flow Nasal Cannula Versus Non-Invasive Ventilation for AECOPD
April 1, 2025
Clinical question: Is high-flow nasal cannula oxygen therapy (HFNC) non-inferior to non-invasive ventilation (NIV) for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in...
Article
Sex Disparities in Opioid Prescription Practices on a Hospital Medicine Service
April 1, 2025
Clinical question: Does patient sex influence opioid prescription patterns during hospitalization and at discharge on general medicine services? Background: Clinicians may have sex- and gender-based...
Article
The CONVINCE Trial: No Reduction in Recurrent Vascular Events with Long-Term Colchicine Use After Ischemic Stroke
April 1, 2025
Clinical question: Does long-term colchicine use plus guideline-based care after ischemic stroke prevent recurrent vascular events? Background: According to the World Health Organization, stroke is...
Article
Risk of Major GI Adverse Events with Use of Potassium Binders in the Hospital
April 1, 2025
Clinical question: Are the new potassium binders, patiromer, and sodium zirconium cyclosilicate (SZC) safer than sodium polystyrene sulfonate (SPS)? Background: Potassium binders were created to...
Article
Racial and Ethnic Bias Through Language Application in Letters of Recommendation
April 1, 2025
Clinical question: Are there racial, ethnic, and underrepresented in medicine (UIM) differences in letters of recommendation and standardized letters of recommendation? Background: Letters of...
Article
Language Discordance Increases Risk of Hospital Readmissions
April 1, 2025
Clinical question: Does language discordance increase hospital readmissions or unplanned emergency department (ED) visits? Background: Studies have shown that language discordance impacts...