Article
The CONVINCE Trial: No Reduction in Recurrent Vascular Events with Long-Term Colchicine Use After Ischemic Stroke
April 1, 2025
Clinical question: Does long-term colchicine use plus guideline-based care after ischemic stroke prevent recurrent vascular events? Background: According to the World Health Organization, stroke is...
Article
Risk of Major GI Adverse Events with Use of Potassium Binders in the Hospital
April 1, 2025
Clinical question: Are the new potassium binders, patiromer, and sodium zirconium cyclosilicate (SZC) safer than sodium polystyrene sulfonate (SPS)? Background: Potassium binders were created to...
Article
Racial and Ethnic Bias Through Language Application in Letters of Recommendation
April 1, 2025
Clinical question: Are there racial, ethnic, and underrepresented in medicine (UIM) differences in letters of recommendation and standardized letters of recommendation? Background: Letters of...
Article
Language Discordance Increases Risk of Hospital Readmissions
April 1, 2025
Clinical question: Does language discordance increase hospital readmissions or unplanned emergency department (ED) visits? Background: Studies have shown that language discordance impacts...
Article
Ammonia Levels Do Not Reflect Severity of Hepatic Encephalopathy in Hospitalized Patients with Cirrhosis
April 1, 2025
Clinical question: Do serum ammonia levels correlate with the severity of overt hepatic encephalopathy (OHE) in hospitalized patients with cirrhosis? Background: Guidelines recommend diagnosing OHE...
Article
Can Salt Stir the Pot? Sodium’s Effect on Heart Failure Clinical Outcomes
April 1, 2025
Clinical question: Is there an association between baseline dietary sodium intake and clinical outcomes in heart failure? Background: Dietary sodium restriction is common advice for patients with...
Article
Moderate IV Fluid Resuscitation is the Goldilocks of Sepsis Mortality in ICU Patients
April 1, 2025
Clinical question: In patients presenting to the intensive care unit (ICU) for sepsis, which intravenous (IV) fluid resuscitation strategy (restrictive, liberal, or moderate) is optimal for lower...
Article
Comparative Effectiveness and Safety of Apixaban, Rivaroxaban, and Warfarin in Patients with Cirrhosis and AF
March 4, 2025
Clinical question: What is the effectiveness and safety of apixaban, rivaroxaban, and warfarin in patients with cirrhosis and atrial fibrillation? Background: The use of direct oral anticoagulants...
Article
Gabapentinoid Use Associated with Increased Risk of Severe Exacerbations in Patientswith COPD
March 4, 2025
Clinical question: Does gabapentinoid use increase the risk of severe exacerbation in patients with chronic obstructive pulmonary disease (COPD)? Background: Gabapentinoids are indicated for the...
Article
Gram-Negative Bacteremia: Early Transition from IV to PO Antibiotic Therapy
March 4, 2025
Clinical question: What is the safety and efficacy of switching from IV to oral antibiotic therapy after three to five days in patients with gram-negative bacteremia? Background: Bacteremia is...