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In the Literature

  • Article

    Acute Care for the Elderly in the Home Environment Increased Physical Activity Levels While Lowering Costs, Health Care Use, and Readmissions

    September 1, 2022

    Dr. Nagaraj Clinical question: Can hospital-level care be provided in the home environment to reduce costs without compromising the quality of care in the U.S.? Background: Inpatient care is...

  • Article

    Mirtazapine is Not an Effective Treatment for Agitation in Dementia

    September 1, 2022

    Ms. Whalen CLINICAL QUESTION: What’s the clinical effectiveness and safety profile of mirtazapine in reducing agitation in dementia relative to placebo? BACKGROUND: Nonpharmacological...

  • Article

    Oral Antibiotics and a Combination Regimen of IV and Oral Antibiotics for Treatment of Acute Uncomplicated Appendicitis Yielded Similar Success Rates

    September 1, 2022

    Dr. Andleeb Clinical question: Are oral antibiotics effective and non-inferior to a combination of intravenous and oral antibiotics?  Background: Evidence over the past 10 years suggests that...

  • Article

    Low-dose Rivaroxaban at Discharge Prevented Some VTE Events at One Month for High-risk Patients Recovering from COVID-19

    September 1, 2022

    Dr. Thazhatuveetil-Kunhahamed Clinical Question: Is extended rivaroxaban prophylaxis (10 mg daily for 35 days) protective against arterial and venous thromboembolism (VTE) events in COVID-19...

  • Article

    The risk for intestinal necrosis with SPS is very low

    August 1, 2022

    Dr. Lippert Clinical question: What is the risk of intestinal necrosis with sodium polystyrene (SPS) for the treatment of hyperkalemia? Background: SPS is a medication that has been available...

  • Article

    Initiation of pulmonary rehabilitation after admission for COPD exacerbation decreases rehospitalizations

    August 1, 2022

    Ms. Langford Clinical question: Does the initiation of pulmonary rehabilitation after hospitalization for a chronic obstructive pulmonary disease (COPD) exacerbation impact...

  • Article

    Tranexamic acid minimized perioperative bleeding in patients undergoing noncardiac surgery

    August 1, 2022

    Dr. Menon Clinical question: Does tranexamic acid reduce the incidence of life-threatening perioperative bleeding in patients undergoing noncardiac surgery without increasing the risk of major...

  • Article

    IV fluid resuscitation at a slow rate in ICU patients did not reduce 90-day mortality

    August 1, 2022

    Mr. Haller Clinical question: Is there a difference in the 90-day mortality for patients admitted to the ICU receiving a fast (999 mL/hour) versus slow (333 mL/hour) IV infusion...

  • Article

    DES reduce the risk of ISR in patients with ICAS compared to BMS

    August 1, 2022

    Dr. Snipe Clinical question: In patients with symptomatic high-grade intracranial atherosclerotic stenosis (ICAS), does the use of a drug-eluting stent (DES) reduce the incidence of in-stent...

  • Article

    Adding a new antihypertensive medication is associated with improved blood pressure lowering

    August 1, 2022

    Dr. Chevli Clinical question: Which is the better strategy for treatment intensification in older patients with hypertension—maximizing the antihypertensive or adding a new...

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