Article
Acetaminophen Rises Systolic Blood Pressure in Those with Hypertension
March 1, 2023
Clinical question: Does regular intake of acetaminophen cause an increase in blood pressure? Background: Acetaminophen is one of the most commonly used analgesics in the world. Because of its...
Article
Early Initiation of Dialysis Improves Survival: To Start or Not to Start
March 1, 2023
Clinical question: What is the ideal estimated glomerular filtration rate (eGFR) at which to start dialysis in patients with advanced chronic kidney disease? Background: Uncertainty exists over the...
Article
Bolus IV 0.9% Saline Leads to Interstitial Permeability Pulmonary Edema in Healthy Volunteers
March 1, 2023
Clinical question: Can intravenous fluid (IVF) administration cause direct lung injury independent of cardiogenic overload? Background: Bolus IVF therapy is a central component to managing...
Article
Effectiveness of Oxycodone Hydrochloride vs. Combination Acetaminophen and Codeine for Subacute Pain After Fractures Managed Surgically: A Randomized Controlled Trial
March 1, 2023
Clinical question: Do less potent opioids suffice for adequate pain control for patients with surgically managed fractures? Background: For post-surgical pain management at time of discharge,...
Article
Nutritional Support Improves Mortality in Frail, Elderly Patients
March 1, 2023
Clinical question: Is there a mortality benefit to optimizing nutritional status for malnourished patients with age-related frailty? Background: Age-related frailty syndrome has been associated with...
Article
Mirtazapine Administration Associated with Moderate Risk of Hyponatremia
March 1, 2023
Clinical question: What is the incidence of hyponatremia in patients treated with mirtazapine? Background: The development of hyponatremia has been associated with selective serotonin inhibitors and...
Article
Aggressive IV Fluids Plus Rectal NSAIDs Don’t Prevent Post-ERCP Pancreatitis
January 3, 2023
Dr. Moulder Clinical question: Does the addition of aggressive intravenous hydration to rectal nonsteroidal anti-inflammatory drugs (NSAIDs) help prevent post-endoscopic retrograde...
Article
Syncopal Event Doesn’t Necessarily Mean Driving Restriction
January 3, 2023
Dr. Young Clinical question: Do patients with first syncopal events suffer more motor vehicle collisions (MVCs) than patients without syncope? Background: Recommendations for driving...
Article
Legionella Risk Model Guides Appropriate Testing
January 3, 2023
Dr. Crane Clinical question: Can select patient demographic data and risk factors help predict Legionella infection better than clinical gestalt or current Infectious Diseases Society of America...
Article
Initiation of Empagliflozin in Hospitalized Patients with Acute Decompensated HF Improves Clinical and Symptomatic Outcomes at 90 Days
January 3, 2023
Dr. Kerley Clinical question: Does initiation of empagliflozin in hospitalized patients with acute decompensated heart failure improve clinical outcomes and symptom burden? Background: Studies...