Article
Gram-Negative Bacteremia: Early Transition from IV to PO Antibiotic Therapy
March 4, 2025
Clinical question: What is the safety and efficacy of switching from IV to oral antibiotic therapy after three to five days in patients with gram-negative bacteremia? Background: Bacteremia is...
Article
Renal Function and Decongestion with ADHF: the ADVOR Trial
March 4, 2025
Clinical question: Does acetazolamide enhance loop diuretic effect in patients with acute decompensated heart failure (ADHF) and how does this combination affect renal function? Background: Nearly...
Article
Finerenone Reduces HF Events in Patients with Preserved Ejection Fraction
March 4, 2025
Clinical question: Does finerenone improve outcomes in patients with heart failure (HF) with mildly reduced or preserved ejection fraction? Background: Steroidal mineralocorticoid receptor...
Article
Empagliflozin After Acute Myocardial Infarction
March 4, 2025
Clinical question: Does empagliflozin improve cardiovascular outcomes in patients who have had an acute myocardial infarction? Background: Studies have shown that empagliflozin improves...
Article
Slower Correction of Sodium in Severe Hyponatremia is Associated with Increased Mortality and Length of Stay
March 4, 2025
Clinical question: Is the sodium correction rate in severe hyponatremia associated with mortality and length of stay? Background: Hyponatremia is commonly encountered in the hospital, with high...
Article
Safety of Diltiazem in Patients Taking Apixaban or Rivaroxaban
March 4, 2025
Clinical question: Does diltiazem increase the risk of major bleeding in patients on apixaban or rivaroxaban? Background: Diltiazem is a potent CYP3A4 inhibitor and a mild P-glycoprotein inhibitor....
Article
Semaglutide Decreases Risk of Kidney Failure, Worsening of Kidney Disease, and Kidney-Related or Cardiovascular Death
March 4, 2025
Clinical question: Does treatment with semaglutide in patients with chronic kidney disease (CKD) and diabetes mellitus (DM) type II reduce the risk of kidney failure, progression of chronic kidney...
Article
Absence of CSF Pleocytosis Prevalent in Encephalitis and Can Delay Empiric Treatment
March 4, 2025
Clinical question: Is there a difference in clinical factors and outcomes among patients with new-onset encephalitis based on whether their initial cerebrospinal fluid (CSF) studies demonstrate the...
Article
Efficacy of AI models in Detecting Clinical Deterioration
January 1, 2025
Clinical question: Can an artificial intelligence (AI) enabled intervention model reduce the risk of clinical deterioration and subsequent care escalation in hospitalized patients? Background:...
Article
Metronidazole-Related Encephalopathy and Neuropathy Associated with IV Administration, Liver Cirrhosis, and CKD
January 1, 2025
Clinical question: What is the prevalence of metronidazole-related neurologic adverse events and what are the risk factors associated with these events? Background: A 2021 study reported neurologic...