Article
SER-109, an Oral Microbiome Therapy for rCDI
April 3, 2023
Dr. Arobelidze Clinical question: In patients with recurrent Clostridioides difficile infection (rCDI), is the use of oral microbiome therapy associated with reduced risk of recurrence of the...
Article
7-day Antibiotic Treatment is Noninferior to 14 Days in Afebrile Men with UTI
April 3, 2023
Dr. Modha Clinical question: Are 14 days of antibiotic treatment better than 7 days in afebrile men with urinary tract infection (UTI)? Background: In the era of antibiotic stewardship, a large...
Article
Oral Tebipenem Pivoxil Hydrobromide is Noninferior to IV Ertapenem in Complicated UTI
April 3, 2023
Dr. Modha Clinical question: Is oral carbapenem tebipenem effective in treating complicated urinary tract infections (UTIs)? Background: Antimicrobial resistance among pathogens, especially...
Article
Endovascular Therapy for Acute Stroke with a Large Ischemic Region
April 3, 2023
Dr. Arobelidze Clinical question: Does endovascular therapy for acute stroke with a large ischemic region have better functional outcomes compared to medical therapy alone without increasing the...
Article
Association of Chronic Medication Adherence with ED Visits and Hospitalizations
April 3, 2023
Dr. Gibson Clinical question: Is there an association between chronic medication adherence and emergency department (ED) visits and hospitalizations? Background: Medication adherence for...
Article
Defining Potential Overuse of PT Consults on Hospital Medicine Services
March 1, 2023
Clinical question: Are physical therapy (PT) consults overused in patients who are at low risk for loss of mobility during hospitalization? Background: Hospital-associated disability can be...
Article
Antibiotic Overuse After Discharge: A Multi-hospital Cohort Study
March 1, 2023
Clinical question: Do patients need continued antibiotics after leaving the hospital? Background: Despite inpatient antimicrobial stewardship programs, studies suggest that up to half of antibiotics...
Article
Endoscopic Intervention Within 6-24 Hours for Non-variceal Upper GI Bleeding Leads to More Favorable Outcomes Compared to Early and Late Intervention
March 1, 2023
Clinical question: How does the timing of endoscopic intervention affect clinical outcomes in patients with acute non-variceal upper gastrointestinal (GI) bleeding? Background: Previous studies have...
Article
Duration of Abstinence from Alcohol Prior to Liver Transplantation Does Not Lead to Increased Survival in Patients with Alcohol-related Liver Disease
March 1, 2023
Clinical question: How does the duration of abstinence from alcohol affect patient survival, allograft survival, and relapse-free survival in patients undergoing liver transplantation? Background:...
Article
MELD 3.0 is a More Equitable and Accurate Predictor of Mortality in Patients with Cirrhosis than MELD-Na
March 1, 2023
Clinical question: How does Model for End-Stage Liver Disease (MELD) 3.0 compare to MELD-Na in regard to liver transplant waitlist mortality? Background: The MELD-Na scoring system has been proven...