Article
Low-Dose Morphine as a Treatment for Chronic Breathlessness
June 1, 2026
Clinical question: Does low-dose, long-acting oral morphine improve self-reported breathlessness at 28 days for adult patients with moderate to severe chronic breathlessness? Background: Chronic...
Article
Telehealth-Based Sepsis Recovery Support Does Not Reduce 90-Day Readmission or Mortality
June 1, 2026
Clinical question: Does a telehealth-based sepsis transition and recovery (STAR) program improve 90-day mortality or hospital readmission among high-risk sepsis survivors? Background: Sepsis...
Article
Discontinuation of APMs Post-Discharge Reduces Adverse Clinical Outcomes
June 1, 2026
Clinical question: Does discontinuation after discharge of antipsychotic medications (APMs) started for hospital delirium result in reduced adverse clinical outcomes compared to APM continuation...
Article
Urea Should Be Considered for Treatment of SIADH-Associated Hyponatremia
June 1, 2026
Clinical question: Is urea a safe and effective treatment option for syndrome of inappropriate antidiuretic hormone secretion (SIADH)-associated hyponatremia? Background: The management of...
Article
De-Escalate Antibiotics for Community-Onset Sepsis After Four Days
June 1, 2026
Clinical question: Is de-escalation of broad-spectrum antibiotics (BSAs) safe on encounter day four in patients with community-onset sepsis with no positive tests for multidrug-resistant organisms...
Article
Digitoxin in Patients with HFrEF May Improve Outcomes
June 1, 2026
Clinical question: In patients with chronic heart failure with reduced ejection fraction (HFrEF, defined as left ventricular ejection fraction of up to 40% with New York Heart Association class...
Article
Private Equity Acquisition of Hospitals is Associated with Decreased Staffing, Increased Patient Transfers, and Increased ED Mortality
June 1, 2026
Clinical question: How does acquisition by private equity firms impact patient outcomes in emergency departments (EDs) and intensive care units (ICUs), and how is this related to changes in hospital...
Article
Pulse Oximetry Discrepancies and Occult Hypoxemia in ICU Patients: Predictors and Clinical Outcomes
June 1, 2026
Clinical question: What is the prevalence of, and what are the risk factors for, occult hypoxemia in ICU patients, and does that impact patient outcomes? Background: The finding of occult hypoxemia,...
Article
Seven Versus 14 Days of Antibiotics for Gram-Negative Bloodstream Infection
June 1, 2026
Clinical question: Is a seven-day course of antibiotics noninferior to a 14-day course for adults with Gram-negative bloodstream infections? Background: Traditionally, the standard duration of...
Article
Fluid Restriction Does Not Improve Outcomes in HF Patients
May 1, 2026
Clinical question: Does a restrictive fluid strategy improve clinical outcomes in heart failure (HF) patients compared to liberal fluid intake? Background: Fluid restriction is often recommended for...