Article
Ultrasound-Facilitated, Catheter- Directed Fibrinolysis for Acute Pulmonary Embolism
October 1, 2026
Clinical Question: Does ultrasound-facilitated, catheter-directed thrombolysis improve clinical outcomes in patients with acute pulmonary embolism (PE), right ventricular strain, and signs of...
Article
Continuing SGLT2 Inhibitors After Urinary Tract Infection
October 1, 2026
Clinical Question: Do SGLT2 inhibitors need to be discontinued in patients with type 2 diabetes mellitus (T2DM) who develop a urinary tract infection (UTI), and what are the clinical implications...
Article
Physician Attire Does Not Influence Patient Trust
October 1, 2026
Clinical Question: Are patients influenced by what physicians wear? Does wearing a white coat instead of surgical scrubs enhance patient trust in their physician and the care they are...
Article
Oral Antithrombotic Monotherapy Is as Effective as Dual Therapy and Likely Safer in Advanced Kidney Disease
October 1, 2026
Clinical Question: Is oral anticoagulant monotherapy safer and more effective than dual antithrombotic therapy in patients with atrial fibrillation (AF), coronary artery disease (CAD), and advanced...
Article
Initial Dose of Diuretics for Heart Failure Admissions Matters
October 1, 2026
Clinical Question: Does initial dosing of diuretics for heart failure admissions change length of stay (LOS) or have any bearing on outcomes? Background: Little is known about the initial dosing of...
Article
Bleeding Risk in Atrial Fibrillation: Diltiazem Versus Metoprolol with Direct Oral Anticoagulants
October 1, 2026
Clinical Question: Among patients with atrial fibrillation (AF) receiving apixaban or rivaroxaban, does concomitant use of diltiazem increase the risk of serious bleeding compared with metoprolol for...
Article
Semaglutide Reduces Alcohol Use in Patients with Obesity Seeking Treatment for Alcohol Use Disorder
October 1, 2026
Clinical Question: Can GLP-1 receptor agonists be used to reduce alcohol use in obese patients motivated to reduce alcohol consumption? Background: Alcohol use disorder accounts for 2.6 million...
Article
PPI Use Is Associated with Increased Risk of Chronic Obstructive Airway Disease Exacerbation
October 1, 2026
Clinical Question: Does proton pump inhibitor (PPI) use increase the risk of obstructive lung disease exacerbation? Background: Previous studies have shown inconsistent results, yielding an unclear...
Article
Apixaban Carries Lower Bleeding Risk Than Rivaroxaban in Acute VTE
September 2, 2026
Clinical Question: In patients with acute venous thromboembolism (VTE), is apixaban associated with a lower risk of clinically relevant bleeding than rivaroxaban? Background: Apixaban and...
Article
Lost in Transition: Teens Falling Through the Cracks After ED Mental Health Visits
September 2, 2026
Clinical Question: Among adolescents with depression or suicidal ideation discharged from the emergency department (ED), what factors are associated with timely primary care follow-up? Background:...