Article
Fluid Restriction Does Not Improve Outcomes in HF Patients
May 1, 2026
Clinical question: Does a restrictive fluid strategy improve clinical outcomes in heart failure (HF) patients compared to liberal fluid intake? Background: Fluid restriction is often recommended for...
Article
Clinical Efficacy of High-Dose Influenza Vaccines in Older Adults
May 1, 2026
Clinical question: In adults aged 65 years and older, is high-dose influenza vaccine more effective than standard-dose vaccine in preventing severe clinical outcomes of influenza...
Article
Should We Aim Higher? Actively Targeting High-Normal Potassium Levels Reduces Ventricular Arrhythmia Events and Hospitalizations in High-Risk Patients
May 1, 2026
Clinical question: Does a treatment strategy targeting high-normal plasma potassium levels (4.5 to 5.0 mmol/L) reduce the risk of ventricular arrhythmias and cardiovascular events in high-risk...
Article
Antibiotic De-Escalation in Adults Hospitalized for Community- Onset Sepsis Without Evidence of Multidrug-Resistant Infection Is Safe
May 1, 2026
Clinical question: In patients hospitalized with community-onset sepsis, does empiric broad-spectrum antibiotic (BSA) de-escalation (on encounter day four), compared with continuation, affect...
Article
Response to Blood Culture Shortage Promotes High Value Care
May 1, 2026
Clinical question: Do diagnostic stewardship interventions in times of crisis lead to sustained change in blood-culture ordering practices? Background: It is estimated that a third of all blood...
Article
Liberal or Restrictive Postoperative Transfusion in Patients at High Cardiac Risk: The TOP Randomized Clinical Trial
May 1, 2026
Clinical question: Does a liberal transfusion strategy decrease the risk of death or major ischemic events after major surgical operations in patients at high risk of cardiac events? Background:...
Article
Predicting Contrast-Associated AKI
May 1, 2026
Clinical question: Do newer prediction models pooled in a systematic review predict contrast-associated acute kidney injury (CA-AKI)? Background: This systematic review updates a previous evaluation...
Article
Using Biomarkers to Guide Antibiotic Duration in Suspected Sepsis
May 1, 2026
Clinical question: Can using daily biomarker-guided protocols, procalcitonin (PCT), or C-reactive protein (CRP) to guide antibiotic duration in adults hospitalized with sepsis safely reduce...
Article
Sodium Bicarbonate Does Not Reduce 90-Day Mortality in Severe Metabolic Acidemia with AKI
May 1, 2026
Clinical question: In critically ill adults with severe metabolic acidemia and moderate to severe acute kidney injury (AKI), does intravenous sodium bicarbonate reduce 90-day all-cause...
Article
Anticoagulation and Antiplatelet Therapy in Patients with AF and Atherosclerosis
April 6, 2026
CLINICAL QUESTION: In patients with atherosclerotic disease and concurrent atrial fibrillation, does adding antiplatelet therapy to oral anticoagulation improve net clinical outcomes compared with...