Article
Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes
February 2, 2026
CLINICAL QUESTION: Does oral semaglutide decrease major cardiovascular events in patients with type 2 diabetes and cardiovascular disease and/or chronic kidney disease? BACKGROUND: Approximately 828...
Article
Discordant Pleural Exudates Are Common and Have a Different Diagnostic Pattern Than Concordant Pleural Exudates
February 2, 2026
CLINICAL QUESTION: How common are discordant pleural fluid exudates, and do they have different diagnostic patterns compared to concordant pleural fluid exudates? BACKGROUND: Pleural effusions are...
Article
CPOE Prompts Reduce Use of Empiric Extended-Spectrum Antibiotics for SSTIs Without Increasing ICU Admissions or Hospital LOS
February 2, 2026
CLINICAL QUESTION: Can computerized provider order entry (CPOE) prompts safely reduce empiric extended-spectrum antibiotic use for noncritically ill, hospitalized patients with skin and soft tissue...
Article
Oral Anticoagulation and Risk of Adverse Clinical Outcomes in VTE
February 2, 2026
CLINICAL QUESTION: How do the three most prescribed oral anticoagulants compare in regard to venous thromboembolism (VTE) recurrence, prevention, and major bleeding? BACKGROUND: Oral anticoagulants...
Article
Comparing Screening Tools for Predicting Sepsis Among Children
January 5, 2026
CLINICAL QUESTION: Which screening tool performs best for early prediction of sepsis and septic shock in children per the Phoenix criteria? BACKGROUND: Early recognition of sepsis remains...
Article
Significant Pathology in Young Infants Presenting with Hypothermia: A Multicenter Study
January 5, 2026
CLINICAL QUESTION: Among infants aged 90 days or younger who present to the emergency department (ED) or hospital with hypothermia, what is the prevalence of significant pathology, and what pathology...
Article
Pediatric Nurses Provide Unique Perspectives on PFC Rounds
January 5, 2026
CLINICAL QUESTION: What are the benefits and barriers to participating in patient-and-family-centered (PFC) rounds from a pediatric nursing perspective? BACKGROUND: Interprofessional PFC rounding...
Article
BRUE Prediction Rules Outperform the AAP Higher-Risk Criteria in Estimating Risk for Serious Underlying Diagnosis
January 5, 2026
CLINICAL QUESTION: Do the recently derived clinical prediction rules for brief resolved unexplained events (BRUE) perform better than the American Academy of Pediatrics (AAP) higher-risk criteria in...
Article
Dexamethasone Non-Inferior to Prednisone or Prednisolone for Treatment of Pediatric Asthma Exacerbations
January 5, 2026
CLINICAL QUESTION: How does dexamethasone compare to prednisone or prednisolone when used to treat pediatric asthma exacerbations? BACKGROUND: Historically, the standard of care steroid choice for...
Article
Pediatric Catatonia’s Medical Turn: Increasing Incidence and Intensifying Treatment
January 5, 2026
CLINICAL QUESTION: Has the incidence, etiology, evaluation, and management of pediatric catatonia changed over time, especially following the COVID-19 pandemic? BACKGROUND: Pediatric catatonia is a...