Article
Should Hospitalists Throw Caution to the Wind? Overly Cautious Correction of Severe Hyponatremia May Lead to Greater Harm Than Good
June 2, 2025
Clinical question: Does the correction rate for hospitalized adults with severe hyponatremia correlate with mortality or length of stay? Background: Hyponatremia is a commonly encountered problem...
Article
Evidence for Reduced-Dose DOAC in Those at High Risk for VTE Recurrence in Extended Phase Anticoagulation: The RENOVE Trial
June 2, 2025
Clinical question: Is extended-phase anticoagulation with dose-reduced direct oral anticoagulants (DOACs) as effective and safe as full-dose DOACs in those with venous thromboembolism (VTE) at high...
Article
Addiction Consultation and Medications for Substance Use Disorders Associated with Reduced 30-Day Readmission Rates
June 2, 2025
Clinical question: In patients with opioid use disorder (OUD) and alcohol use disorder (AUD), do addiction consultations or medications for opioid use disorder (MOUD) and alcohol use disorder (MAUD)...
Article
Health Systems and Prescribers Can Favor a Single Triple-Therapy Inhaler in COPD that Both Improves Patient Outcomes and Reduces the Climate Impacts of Healthcare
June 2, 2025
Clinical question: How do the two available (U.S. market) single triple-therapy inhalers compare in terms of safety and efficacy for patients with chronic obstructive pulmonary disease (COPD), with...
Article
Naturalized Citizens and Noncitizen Immigrant Healthcare Workers are Important Members of the Workforce
June 2, 2025
Clinical question: How do the Trump administration’s plans for deporting undocumented immigrants and some individuals with temporary protected status impact the already strained healthcare...
Article
Perioperative Strategy for RASI
May 1, 2025
Clinical question: Should renin-angiotensin system inhibitors (RASI) be continued or discontinued before major noncardiac surgery? Background: Continuation of RASI perioperatively can predispose to...
Article
Continuous Versus Intermittent Infusion of β-Lactam Antibiotics in Critically Ill Patients with Sepsis
May 1, 2025
Clinical question: Does continuous infusion of β-lactam antibiotics reduce 90-day mortality compared with intermittent infusion in critically ill patients with sepsis? Background: Sepsis, a...
Article
Healthcare Worker Well-Being After a 5-hour Continuous Communication and Intervention: The Well-B Randomized Clinical Trial
May 1, 2025
Clinical question: Does a brief continuing education intervention improve the well-being of healthcare workers (HCWs)? Background: HCWs’ well-being has been severely impacted, particularly after...
Article
MOUD and Behavioral Health Interventions after Nonfatal Drug Overdose
May 1, 2025
Clinical question: How often are medications for opioid use disorder (MOUD), naloxone, and behavioral health services prescribed after a nonfatal drug overdose, and what is the association between...
Article
Lactated Ringer’s Administration Improved Outcomes Over Normal Saline Administration During Sickle Cell Vaso-Occlusive Episode
May 1, 2025
Clinical question: Is there a difference in the effectiveness of sickle cell vaso-occlusive episode treatment with lactated Ringer’s (LR) solution versus normal saline (NS)? Background: Initial...