Article
Comparison of Hospital Mortality and Readmission Rates by Physician and Patient Sex
January 1, 2025
Clinical question: Are hospital mortality and readmission rates associated with physician sex, and do these associations vary by patient sex? Background: Prior studies indicate that physician...
Article
Inhaled Amikacin in the First 72 Hours of Mechanical Ventilation Reduced the Incidence of VAP
January 1, 2025
Clinical question: Does inhaled amikacin reduce the incidence of ventilator-associated pneumonia (VAP) in critically ill patients? Background: VAP is a common and serious complication in patients on...
Article
90-Day Mortality Among Septic Patients Given Piperacillin-Tazobactam Versus Cefepime
January 1, 2025
Clinical question: In patients with undifferentiated sepsis without an indication for anaerobic coverage, is there increased mortality with the combined use of vancomycin/piperacillin-tazobactam...
Article
Hydrocortisone Plus Fludrocortisone for CAP-Related Septic Shock
January 1, 2025
Clinical question: Does hydrocortisone and fludrocortisone reduce all-cause mortality among patients with septic shock due to community-acquired pneumonia (CAP)? Background: A meta-analysis of 17...
Article
Empagliflozin After Acute Myocardial Infarction (EMPACT-MI)
January 1, 2025
Clinical question: Does starting empagliflozin for patients with acute myocardial infarction (AMI) and new onset systolic heart failure (HF) or congestive symptoms reduce the risk of first...
Article
Clinical Risk Score Predicts Arterial Thrombosis in Survivors of Intracranial Hemorrhage
January 1, 2025
Clinical question: Among survivors of hemorrhagic stroke, who is at high long-term risk of arterial thrombosis? Background: Patients who survive intracerebral hemorrhage (ICH) are at increased risk...
Article
Implementing and Evaluating a DBN Initiative in a Large Tertiary Care Urban Hospital
January 1, 2025
Clinical question: What is the impact of implementing discharge before noon (DBN) initiatives on discharge time and other factors such as length of stay (LOS), 30-day readmission, and ED boarding...
Article
Understanding Potentially Preventable 7-Day Readmission Rates in Medical Oncology Patients
January 1, 2025
Clinical question: What are the rates and the underlying risk factors for seven-day, unplanned, potentially preventable re-admission (PPR), among solid tumor patients in a medical oncology...
Article
Higher Rates of Major Hemorrhage with Rivaroxaban and Warfarin
December 2, 2024
Clinical question: How effective and safe are apixaban versus rivaroxaban versus warfarin in patients with cirrhosis and nonvalvular atrial fibrillation (AF)? Background: Apixaban, rivaroxaban, and...
Article
Detectable MNPs in Carotid Artery Plaques Are Associated with a Higher Risk of Myocardial Infarction, Stroke, or Death
December 2, 2024
Clinical question: Do patients with carotid artery plaque containing detectable microplastics and nanoplastics (MNPs) have a higher risk of myocardial infarction, stroke, or death? Background:...