Article
Using AI/NLP to Improve Clinical Efficiency and Drive Patient-Centered Care in Cancer Research
October 1, 2025
CLINICAL QUESTION: Should clinicians use artificial intelligence with natural language processing (AI/NLP) to assess patient messages and review patient concerns to further develop meaningful, novel...
Article
Patients View Physicians as More Compassionate and Trustworthy When Their Message is Optimistic
October 1, 2025
CLINICAL QUESTION: Does a pessimistic prognosis alter how patients view their physician? BACKGROUND: Although terminally ill patients often prefer honest prognostic information, physicians have...
Article
IV Iron Lowers the Risk of HF Hospitalization for Patients with HF (EF <50%) and Iron Deficiency
October 1, 2025
CLINICAL QUESTION: Does IV iron reduce the risk of heart failure (HF) hospitalization and/or cardiovascular mortality in patients with systolic heart failure (EF <50%) and iron...
Article
AI-Assisted Patient Screening Improves Rate of Eligibility Determination and Enrollment Compared to Traditional Manual Methods
October 1, 2025
CLINICAL QUESTION: This study compares the efficiency of an AI-assisted screening tool versus manual chart reviews for unstructured data in assessing patient eligibility based on specific...
Article
SGLT-2 Inhibitors’ Increased Risk of PAD-Related Surgical Events Compared to DPP-4 Inhibitors’ Risk When Used as Add-On Therapy in Diabetes
October 1, 2025
CLINICAL QUESTION: Do sodium-glucose cotransporter-2 (SGLT-2) inhibitors, as add-on therapy for diabetes, increase the risk of amputations, stent placement, or revascularization surgeries compared...
Article
Liberal Fluid Intake Does Not Worsen Outcomes in CHF
October 1, 2025
CLINICAL QUESTION: Does advising liberal fluid intake, compared to fluid restriction, improve health status without compromising safety in stable chronic heart failure (CHF)? BACKGROUND: Fluid...
Article
Lower Threshold Blood Pressure Associated with Reduced Postpartum ED Visits
September 3, 2025
Clinical question: Does tighter blood pressure (BP) control postpartum reduce emergency department (ED) visits for postpartum patients, and if yes, what are the cardiovascular risk...
Article
Early Thoracentesis Does Not Improve Clinical Outcomes in Acute HF
September 3, 2025
Clinical question: Does upfront thoracentesis improve short-term clinical outcomes for patients with acute heart failure (HF)? Background: Thoracentesis is being performed at increasing rates in...
Article
Albumin-Adjusted Calcium: Poorly Predictive, Yet Routinely Used
September 3, 2025
Clinical question: Is albumin-adjusted calcium a reliable surrogate for determining true calcium status, particularly when compared to ionized calcium, in adult patients? Background:...
Article
Pre-Treatment with IV Calcium Prior to IV Diltiazem Prevents Hypotension in AF
September 3, 2025
Clinical question: Can pre-treatment with IV calcium prevent hypotension in patients receiving IV diltiazem for atrial fibrillation (AF) or atrial flutter? Background: AF is the most commonly...