Canagliflozin protects diabetic kidneys


Background: Type 2 diabetes is the leading cause of kidney failure worldwide. Few treatment options exist to help improve on this outcome in patients with chronic kidney disease.

Dr. Matthew Hoegh, a hospitalist at the University of Colorado at Denver, Aurora

Dr. Matthew Hoegh

Study design: CREDENCE (industry-sponsored) double-blind, randomized placebo-controlled trial.

Setting: 695 sites in 34 countries, 4,401 patients.

Synopsis: The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. Canagliflozin reduced serious adverse renal events or death from renal or cardiovascular causes at 2.62 years (11.1% vs. 15.5% with placebo; number needed to treat, 23).Bottom line: Canagliflozin lowered serious adverse renal events people with type 2 diabetics who also had chronic kidney disease.

Citation: Perkovic V et al. Canagliflozin and renal outcomes in type 2 diabetes and nephropathy. N Engl J Med. 2019 Apr 14. doi: 10-1056/NEJMoa1811744.

Dr. Hoegh is a hospitalist at the University of Colorado at Denver, Aurora.

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