Article
Predicting Contrast-Associated AKI
May 1, 2026
Clinical question: Do newer prediction models pooled in a systematic review predict contrast-associated acute kidney injury (CA-AKI)? Background: This systematic review updates a previous evaluation...
Article
Sodium Bicarbonate Does Not Reduce 90-Day Mortality in Severe Metabolic Acidemia with AKI
May 1, 2026
Clinical question: In critically ill adults with severe metabolic acidemia and moderate to severe acute kidney injury (AKI), does intravenous sodium bicarbonate reduce 90-day all-cause...
Article
What’s New in the 2025 IDSA Updates for Complicated UTIs?
April 6, 2026
Case: An 80-year-old man with Alzheimer’s dementia presents with fever, worsening suprapubic discomfort, and new right flank pain. He began ciprofloxacin the day before for a presumed urinary tract...
Article
Limited Access to Pre-Dialysis Care Associated with Lower Rates of Usable AV Dialysis Access at Dialysis Initiation for Hispanic Patients
March 2, 2026
CLINICAL QUESTION: Is there a relationship between access to pre-dialysis nephrology care and the presence of usable arteriovenous (AV) access at dialysis initiation among Hispanic...
Article
To Pair Furosemide with Albumin or Not?
December 1, 2025
Furosemide, a highly protein-bound organic acid, promotes free water clearance and natriuresis by entering the proximal tubules of the kidneys and blocking the sodium-potassium-chloride...
Article
Weekly Tirzepatide Increases the Rate of Resolution for MASH
November 3, 2025
CLINICAL QUESTION: Does tirzepatide improve the rate of resolution of Metabolic Dysfunction-Associated Steatohepatitis (MASH) or decrease the fibrosis stage in patients with steatohepatitis and...
Article
Cystatin C in the Inpatient Setting: Enhancing Kidney Function Assessment
October 1, 2025
A 68-year-old man on chronic steroids for amiodarone-induced thyroiditis presented with pneumonia, hypotension, and encephalopathy. Though the pneumonia resolved, his encephalopathy worsened, and...
Article
Interpreting Pyuria on Urinalysis in Geriatric Patients: Context Matters
June 2, 2025
A 75-year-old female nursing-home resident with mild cognitive impairment is admitted to the hospital for two days of confusion, agitation, and weakness. She denies any genitourinary symptoms,...
Stewardship Prompts to Improve Antibiotic Selection for UTI
May 1, 2025
Clinical question: Can computerized provider order entry (CPOE) prompts reduce the use of empiric extended-spectrum antibiotics in patients with urinary tract infections (UTI)? Background: UTIs...
Article
Effects of Semaglutide on CKD in Patients with Type 2 Diabetes: the FLOW Trial
April 1, 2025
Clinical question: Does treatment with semaglutide in patients with type 2 diabetes and chronic kidney disease (CKD) prevent the progression of CKD or death from kidney and cardiovascular...