Article
Continuing SGLT2 Inhibitors After Urinary Tract Infection
October 1, 2026
Clinical Question: Do SGLT2 inhibitors need to be discontinued in patients with type 2 diabetes mellitus (T2DM) who develop a urinary tract infection (UTI), and what are the clinical implications...
Article
Oral Antithrombotic Monotherapy Is as Effective as Dual Therapy and Likely Safer in Advanced Kidney Disease
October 1, 2026
Clinical Question: Is oral anticoagulant monotherapy safer and more effective than dual antithrombotic therapy in patients with atrial fibrillation (AF), coronary artery disease (CAD), and advanced...
Article
Targeted Inpatient Correction of Chronic Hyponatremia Does Not Improve Short-Term Clinical Outcomes
September 2, 2026
Clinical Question: Does targeted correction of chronic hyponatremia in hospitalized patients reduce 30-day mortality or rehospitalization compared with routine care? Background: Chronic hyponatremia...
Article
Discontinuation of ACEIs/ARBs During AKI in Hospitalized Patients Decreases All-Cause Mortality
September 2, 2026
Clinical Question: Does discontinuation of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) during an episode of acute kidney injury (AKI) improve clinical...
Article
Daily Fish-Oil Supplementation Reduced Serious Cardiovascular Events in Patients with End-Stage Kidney Disease Who Receive Maintenance Hemodialysis
September 2, 2026
Clinical Question: Does daily supplementation with omega-3 polyunsaturated fatty acids reduce cardiovascular events in patients on maintenance hemodialysis? Background: Cardiovascular disease is the...
Article
Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury: BICARICU-2
June 18, 2026
Mount Sinai Med-Lit Review Clinical question: Does sodium bicarbonate infusion in patients with moderate to severe acute kidney injury and severe metabolic acidosis reduce 90-day all-cause...
Article
Predicting Contrast-Associated AKI
May 1, 2026
Clinical question: Do newer prediction models pooled in a systematic review predict contrast-associated acute kidney injury (CA-AKI)? Background: This systematic review updates a previous evaluation...
Article
Sodium Bicarbonate Does Not Reduce 90-Day Mortality in Severe Metabolic Acidemia with AKI
May 1, 2026
Clinical question: In critically ill adults with severe metabolic acidemia and moderate to severe acute kidney injury (AKI), does intravenous sodium bicarbonate reduce 90-day all-cause...
Article
What’s New in the 2025 IDSA Updates for Complicated UTIs?
April 6, 2026
Case: An 80-year-old man with Alzheimer’s dementia presents with fever, worsening suprapubic discomfort, and new right flank pain. He began ciprofloxacin the day before for a presumed urinary tract...
Article
Limited Access to Pre-Dialysis Care Associated with Lower Rates of Usable AV Dialysis Access at Dialysis Initiation for Hispanic Patients
March 2, 2026
CLINICAL QUESTION: Is there a relationship between access to pre-dialysis nephrology care and the presence of usable arteriovenous (AV) access at dialysis initiation among Hispanic...