This article last updated 3/30/20. (Disclaimer: The information in this article may not be updated regularly. For more COVID-19 coverage, bookmark our COVID-19 updates page. The editors of The Hospitalist encourage clinicians to also review information on the CDC website and on the AHA website.)
An infectious disease outbreak that began in December 2019 in Wuhan (Hubei Province), China, was found to be caused by the seventh strain of coronavirus, initially called the novel (new) coronavirus. The virus was later labeled as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease caused by SARS-CoV-2 is named COVID-19. Until 2019, only six strains of human coronaviruses had previously been identified.
As of March 30, 2020, according to the U.S. Centers for Disease Control and Prevention, COVID-19 has been detected in at least 199 countries and has spread to every contintent except Antarctica. More than 753,346 people have become infected globally, and at least 36,273 have died. Based on the cases detected and tested in the United States through the U.S. public health surveillance systems, we have had 146,027 confirmed cases and 2,650 deaths.
On March 11, 2020, the World Health Organization formally declared the COVID-19 outbreak to be a pandemic.
As the number of cases increases in the United States, we hope to provide answers about some common questions regarding COVID-19. The information summarized in this article is obtained and modified.
What are the clinical features of COVID-19?
Ranges from asymptomatic infection, a mild disease with nonspecific signs and symptoms of acute respiratory illness, to severe pneumonia with respiratory failure and septic shock.
Who is at risk for COVID-19?
Persons who have had prolonged, unprotected close contact with a patient with symptomatic, confirmed COVID-19, and those with recent travel to China, especially Hubei Province.
Who is at risk for severe disease from COVID-19?
Older adults and persons who have underlying chronic medical conditions, such as immunocompromising conditions.
How is COVID-19 spread?
Person-to-person, mainly through respiratory droplets. SARS-CoV-2 has been isolated from upper respiratory tract specimens and bronchoalveolar lavage fluid.
When is someone infectious?
Incubation period may range from 2 to 14 days. Detection of viral RNA does not necessarily mean that infectious virus is present, as it may be detectable in the upper or lower respiratory tract for weeks after illness onset.
Can someone who has been quarantined for COVID-19 spread the illness to others?
For COVID-19, the period of quarantine is 14 days from the last date of exposure, because 14 days is the longest incubation period seen for similar coronaviruses. Someone who has been released from COVID-19 quarantine is not considered a risk for spreading the virus to others because they have not developed illness during the incubation period.
Can a person test negative and later test positive for COVID-19?
Yes. In the early stages of infection, it is possible the virus will not be detected.
Do patients with confirmed or suspected COVID-19 need to be admitted to the hospital?
Not all patients with COVID-19 require hospital admission. Patients whose clinical presentation warrants inpatient clinical management for supportive medical care should be admitted to the hospital under appropriate isolation precautions. The decision to monitor these patients in the inpatient or outpatient setting should be made on a case-by-case basis.
What should you do if you suspect a patient for COVID-19?
Immediately notify both infection control personnel at your health care facility and your local or state health department. State health departments that have identified a person under investigation (PUI) should immediately contact CDC’s Emergency Operations Center (EOC) at 770-488-7100 and complete a COVID-19 PUI case investigation form.
CDC’s EOC will assist local/state health departments to collect, store, and ship specimens appropriately to CDC, including during after-hours or on weekends/holidays.
What type of isolation is needed for COVID-19?
Airborne Infection Isolation Room (AIIR) using Standard, Contact, and Airborne Precautions with eye protection.
How should health care personnel protect themselves when evaluating a patient who may have COVID-19?
Standard Precautions, Contact Precautions, Airborne Precautions, and use eye protection (e.g., goggles or a face shield).
What face mask do health care workers wear for respiratory protection?
A fit-tested NIOSH-certified disposable N95 filtering facepiece respirator should be worn before entry into the patient room or care area. Disposable respirators should be removed and discarded after exiting the patient’s room or care area and closing the door. Perform hand hygiene after discarding the respirator.
If reusable respirators (e.g., powered air purifying respirator/PAPR) are used, they must be cleaned and disinfected according to manufacturer’s reprocessing instructions prior to re-use.
What should you tell the patient if COVID-19 is suspected or confirmed?
Patients with suspected or confirmed COVID-19 should be asked to wear a surgical mask as soon as they are identified, to prevent spread to others.
Should any diagnostic or therapeutic interventions be withheld because of concerns about the transmission of COVID-19?
How do you test a patient for SARS-CoV-2, the virus that causes COVID-19?
At this time, diagnostic testing for COVID-19 can be conducted only at CDC.
The CDC recommends collecting and testing multiple clinical specimens from different sites, including two specimen types – lower respiratory and upper respiratory (nasopharyngeal and oropharyngeal aspirates or washes, nasopharyngeal and oropharyngeal swabs, bronchioalveolar lavage, tracheal aspirates, sputum, and serum) using a real-time reverse transcription PCR (rRT-PCR) assay for SARS-CoV-2. Specimens should be collected as soon as possible once a PUI is identified regardless of the time of symptom onset. Turnaround time for the PCR assay testing is about 24-48 hours.
Testing for other respiratory pathogens should not delay specimen shipping to CDC. If a PUI tests positive for another respiratory pathogen, after clinical evaluation and consultation with public health authorities, they may no longer be considered a PUI.