Article
Apixaban Carries Lower Bleeding Risk Than Rivaroxaban in Acute VTE
September 2, 2026
Clinical Question: In patients with acute venous thromboembolism (VTE), is apixaban associated with a lower risk of clinically relevant bleeding than rivaroxaban? Background: Apixaban and...
Article
Pleural Effusions Requiring Drainage Are Associated with Lower Survival in Veterans with Cancer, CHF, or Pneumonia
September 2, 2026
Clinical Question: Does the presence of a clinically significant pleural effusion have an impact on survival in patients with an admitting diagnosis of cancer, congestive heart failure (CHF), or...
Article
Anti-Xa Monitoring During Therapeutic LMWH Use Leads to Frequent Dose Changes Without Clear Evidence of Improved Clinical Outcomes
September 2, 2026
Clinical Question: In patients receiving therapeutic low-molecular-weight heparin (LMWH), does anti-Xa monitoring with subsequent dose adjustment improve bleeding or thrombotic outcomes? Background:...
High-Dose Influenza Vaccine Reduces Hospitalizations
August 3, 2026
Clinical Question: In older adults, does high-dose influenza vaccination result in a lower rate of hospitalizations for influenza or pneumonia compared with standard-dose regimens? Background: Older...
Article
Low-Dose Morphine as a Treatment for Chronic Breathlessness
June 1, 2026
Clinical question: Does low-dose, long-acting oral morphine improve self-reported breathlessness at 28 days for adult patients with moderate to severe chronic breathlessness? Background: Chronic...
Article
Optimal Timing of Anticoagulation Initiation After Ischemic Stroke in Patients with AF
April 6, 2026
CLINICAL QUESTION: In patients with atrial fibrillation (AF) and acute ischemic stroke, does early anticoagulation initiation (within four days) improve outcomes compared to delayed...
Article
Low-Dose Glucocorticoids Reduce Mortality in CAP
April 6, 2026
CLINICAL QUESTION: Do glucocorticoids reduce mortality in hospitalized adults with community-acquired pneumonia in a resource-limited setting? BACKGROUND: The use of glucocorticoids as adjunctive...
Article
Early TAVR Improved Outcomes for Elderly Patients with Asymptomatic Severe AS
March 2, 2026
CLINICAL QUESTION: In patients with asymptomatic severe aortic stenosis (AS) and preserved ejection fraction (EF), will early-intervention transcatheter aortic-valve replacement (TAVR), compared to...
Article
Navigational Bronchoscopy is Diagnostically Non-Inferior Compared to Transthoracic Needle Biopsy in Evaluation of Lung Nodules
February 2, 2026
CLINICAL QUESTION: In the evaluation of peripheral lung nodules, how does navigational bronchoscopy compare to transthoracic needle biopsy regarding diagnostic accuracy and procedural...
Article
Adding Budesonide to Albuterol Rescue Therapy in Patients with Mild Asthma Decreases Severe Exacerbations
February 2, 2026
CLINICAL QUESTION: Is as-needed albuterol-budesonide superior to albuterol alone in patients with mild asthma? BACKGROUND: Although patients with mild asthma are often considered low risk, they...