Article
IV Sodium Thiosulphate for Calciphylaxis of CKD: A Systematic Review and Meta-analysis
August 1, 2024
Clinical question: Does IV sodium thiosulphate improve skin lesions and survival in patients with chronic kidney disease (CKD) experiencing calciphylaxis? Background: Calciphylaxis, also called...
Article
DOACs Versus Warfarin Across the Spectrum of Kidney Function
April 1, 2024
Clinical question: How safe are direct oral anticoagulants (DOACs) to use in kidney dysfunction? Background: DOACs are increasingly being used in patients with kidney dysfunction. DOACs are cleared,...
Article
Associations of Apixaban Dose with Safety and Effectiveness Outcomes in Patients with Atrial Fibrillation and Severe CKD
April 1, 2024
Clinical question: Is the use of standard-dose apixaban based on creatinine criteria placing patients at higher risk of bleeding? Background: The U.S. Food and Drug Administration recommends...
Article
Risk for CKD Progression After AKI
February 1, 2024
Dr. Dalal Clinical question: Is acute kidney injury (AKI) associated with subsequent worsening of renal function trajectory in patients with chronic kidney disease (CKD)? Background: Prior...
Article
Apixaban Has Lower Risk of Bleeding Than Warfarin in ESKD
June 1, 2023
Dr. Leiner Clinical question: In patients with end-stage kidney disease (ESKD) and venous thromboembolism (VTE), does apixaban have a lower bleeding risk and VTE recurrence than...
Article
Early Initiation of Dialysis Improves Survival: To Start or Not to Start
March 1, 2023
Clinical question: What is the ideal estimated glomerular filtration rate (eGFR) at which to start dialysis in patients with advanced chronic kidney disease? Background: Uncertainty exists over the...
Article
Prediction of End-stage Kidney Disease Using Estimated Glomerular Filtration Rate With and Without Race
October 3, 2022
Dr. Choksi Clinical question: Does using old and new chronic kidney disease epidemiology collaboration (CKD-EPI) equations alone have a better predictive value for two-year incidence of end-stage...
Article
Can I use DOAC in a patient with renal disease?
February 3, 2022
Case A 76-year-old man is diagnosed with non-valvular atrial fibrillation. His comorbid conditions are hypertension, diabetes complicated by neuropathy, and chronic kidney disease stage 3. His...
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News
Apixaban a reasonable alternative to warfarin in patients with severe renal impairment
December 9, 2021
Is apixaban a safe alternative to warfarin in patients with severe renal impairment?
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News
Timing of initiation of renal-replacement therapy in acute kidney injury
December 8, 2021
In critically ill patients, does early renal-replacement therapy (RRT), compared with standard therapy, improve death from any cause at 90 days?
