Article
ASCO Guideline for the Use of Opioids for Adults with Cancer or Cancer Treatment
October 1, 2024
Ms. Parikh Clinical question: What are expert recommendations for the use of opioids for adults with pain from cancer? Background: Pain is a common consequence of cancer and cancer treatment....
Article
ACLF Grade 3 Predicts Risk of Respiratory Failure with Terlipressin Use
October 1, 2024
Ms. Boyle Clinical question: Which risk factors predict new-onset respiratory failure during terlipressin use for the treatment of patients with rapidly deteriorating kidney function attributed...
Article
The STRONG-HF Trial: Evaluating the Safety, Tolerability, and Effectiveness of Up-titrating GDMT in Acute Heart Failure
August 1, 2024
Clinical question: Does rapid up-titration of guideline-directed medical therapies (GDMT) following admission for acute heart failure improve patient outcomes? Background: GDMT provides...
Article
No Difference in Safety or Mortality with Restrictive Versus Liberal Fluid Resuscitation Strategy for Ongoing Resuscitation in ICU Patients with Septic Shock
August 1, 2024
Clinical question: Are there safety or mortality benefits to the use of a more restrictive versus liberal IV fluid strategy for ongoing IV fluid resuscitation in critically ill patients with septic...
Article
Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes
August 1, 2024
Clinical question: Is the treatment strategy with ticagrelor superior to prasugrel in acute coronary syndrome (ACS) with planned invasive evaluation at one year? Background: Dual antiplatelet...
Article
IV Sodium Thiosulphate for Calciphylaxis of CKD: A Systematic Review and Meta-analysis
August 1, 2024
Clinical question: Does IV sodium thiosulphate improve skin lesions and survival in patients with chronic kidney disease (CKD) experiencing calciphylaxis? Background: Calciphylaxis, also called...
Article
Maximizing Oral Iron Supplementation Absorption in Women
August 1, 2024
Clinical question: Is oral iron supplementation absorption influenced by the timing and/or nutritional elements concurrently consumed in healthy iron-deficient women? Background: Current guidelines...
Article
Frequent PT in Hospital Increases Home Discharge for Pneumonia Patients
June 3, 2024
Clinical question: Does increased frequency of physical therapy (PT) for hospitalized pneumonia patients affect their discharge to home versus to a post-acute care facility? Background: Each year,...
Article
Elevated fibrinogen and D-dimer relative to C-reactive protein linked to cognitive deficits post-COVID-19 hospitalization
June 3, 2024
Clinical question: Are acute blood biomarker profiles predictive of cognitive deficits following COVID-19 hospitalizations? Background: Cognitive deficits have been observed in many patients after...
Article
Liberal transfusion strategy in acute myocardial infarction patients with anemia not shown to significantly reduce recurrent MI or death
June 3, 2024
Clinical question: What should be the transfusion target for patients hospitalized for myocardial infarction (MI) with anemia? Background: Data on the optimal transfusion target for patients with MI...