Article
Ammonia Levels Do Not Reflect Severity of Hepatic Encephalopathy in Hospitalized Patients with Cirrhosis
April 1, 2025
Clinical question: Do serum ammonia levels correlate with the severity of overt hepatic encephalopathy (OHE) in hospitalized patients with cirrhosis? Background: Guidelines recommend diagnosing OHE...
Article
Can Salt Stir the Pot? Sodium’s Effect on Heart Failure Clinical Outcomes
April 1, 2025
Clinical question: Is there an association between baseline dietary sodium intake and clinical outcomes in heart failure? Background: Dietary sodium restriction is common advice for patients with...
Article
Moderate IV Fluid Resuscitation is the Goldilocks of Sepsis Mortality in ICU Patients
April 1, 2025
Clinical question: In patients presenting to the intensive care unit (ICU) for sepsis, which intravenous (IV) fluid resuscitation strategy (restrictive, liberal, or moderate) is optimal for lower...
Article
Comparative Effectiveness and Safety of Apixaban, Rivaroxaban, and Warfarin in Patients with Cirrhosis and AF
March 4, 2025
Clinical question: What is the effectiveness and safety of apixaban, rivaroxaban, and warfarin in patients with cirrhosis and atrial fibrillation? Background: The use of direct oral anticoagulants...
Article
Gabapentinoid Use Associated with Increased Risk of Severe Exacerbations in Patientswith COPD
March 4, 2025
Clinical question: Does gabapentinoid use increase the risk of severe exacerbation in patients with chronic obstructive pulmonary disease (COPD)? Background: Gabapentinoids are indicated for the...
Article
Gram-Negative Bacteremia: Early Transition from IV to PO Antibiotic Therapy
March 4, 2025
Clinical question: What is the safety and efficacy of switching from IV to oral antibiotic therapy after three to five days in patients with gram-negative bacteremia? Background: Bacteremia is...
Article
Renal Function and Decongestion with ADHF: the ADVOR Trial
March 4, 2025
Clinical question: Does acetazolamide enhance loop diuretic effect in patients with acute decompensated heart failure (ADHF) and how does this combination affect renal function? Background: Nearly...
Article
Finerenone Reduces HF Events in Patients with Preserved Ejection Fraction
March 4, 2025
Clinical question: Does finerenone improve outcomes in patients with heart failure (HF) with mildly reduced or preserved ejection fraction? Background: Steroidal mineralocorticoid receptor...
Article
Empagliflozin After Acute Myocardial Infarction
March 4, 2025
Clinical question: Does empagliflozin improve cardiovascular outcomes in patients who have had an acute myocardial infarction? Background: Studies have shown that empagliflozin improves...
Article
Slower Correction of Sodium in Severe Hyponatremia is Associated with Increased Mortality and Length of Stay
March 4, 2025
Clinical question: Is the sodium correction rate in severe hyponatremia associated with mortality and length of stay? Background: Hyponatremia is commonly encountered in the hospital, with high...