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An Official Publication of
  • Clinical
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In the Literature

  • Article

    Ammonia Levels Do Not Reflect Severity of Hepatic Encephalopathy in Hospitalized Patients with Cirrhosis

    April 1, 2025

    Clinical question: Do serum ammonia levels correlate with the severity of overt hepatic encephalopathy (OHE) in hospitalized patients with cirrhosis? Background: Guidelines recommend diagnosing OHE...

  • Article

    Can Salt Stir the Pot? Sodium’s Effect on Heart Failure Clinical Outcomes

    April 1, 2025

    Clinical question: Is there an association between baseline dietary sodium intake and clinical outcomes in heart failure? Background: Dietary sodium restriction is common advice for patients with...

  • Article

    Moderate IV Fluid Resuscitation is the Goldilocks of Sepsis Mortality in ICU Patients

    April 1, 2025

    Clinical question: In patients presenting to the intensive care unit (ICU) for sepsis, which intravenous (IV) fluid resuscitation strategy (restrictive, liberal, or moderate) is optimal for lower...

  • Article

    Comparative Effectiveness and Safety of Apixaban, Rivaroxaban, and Warfarin in Patients with Cirrhosis and AF

    March 4, 2025

    Clinical question: What is the effectiveness and safety of apixaban, rivaroxaban, and warfarin in patients with cirrhosis and atrial fibrillation? Background: The use of direct oral anticoagulants...

  • Article

    Gabapentinoid Use Associated with Increased Risk of Severe Exacerbations in Patientswith COPD

    March 4, 2025

    Clinical question: Does gabapentinoid use increase the risk of severe exacerbation in patients with chronic obstructive pulmonary disease (COPD)? Background: Gabapentinoids are indicated for the...

  • Article

    Gram-Negative Bacteremia: Early Transition from IV to PO Antibiotic Therapy

    March 4, 2025

    Clinical question: What is the safety and efficacy of switching from IV to oral antibiotic therapy after three to five days in patients with gram-negative bacteremia? Background: Bacteremia is...

  • Article

    Renal Function and Decongestion with ADHF: the ADVOR Trial

    March 4, 2025

    Clinical question: Does acetazolamide enhance loop diuretic effect in patients with acute decompensated heart failure (ADHF) and how does this combination affect renal function? Background: Nearly...

  • Article

    Finerenone Reduces HF Events in Patients with Preserved Ejection Fraction

    March 4, 2025

    Clinical question: Does finerenone improve outcomes in patients with heart failure (HF) with mildly reduced or preserved ejection fraction? Background: Steroidal mineralocorticoid receptor...

  • Article

    Empagliflozin After Acute Myocardial Infarction

    March 4, 2025

    Clinical question: Does empagliflozin improve cardiovascular outcomes in patients who have had an acute myocardial infarction? Background: Studies have shown that empagliflozin improves...

  • Article

    Slower Correction of Sodium in Severe Hyponatremia is Associated with Increased Mortality and Length of Stay

    March 4, 2025

    Clinical question: Is the sodium correction rate in severe hyponatremia associated with mortality and length of stay? Background: Hyponatremia is commonly encountered in the hospital, with high...

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