Article
Oral Versus Extended-Release Injectable Naltrexone for Hospitalized Patients With AUD
July 31, 2025
Clinical question: Is there a difference in effectiveness between oral and injectable naltrexone at discharge for alcohol use disorder (AUD)? Background: AUD is common among inpatients, and most do...
Article
IV Ferric Carboxymaltose in Heart Failure with Iron Deficiency
July 31, 2025
Clinical question: Does IV ferric carboxymaltose improve clinical outcomes in patients with heart failure (HF) and iron deficiency? Background: Iron deficiency affects up to half of patients with HF...
Article
Feeding Tube Use Still Common in Hospitalized Older Adults with Dementia
July 31, 2025
Clinical question: How frequently are feeding tubes placed during hospitalization in older adults with dementia, and what patient or regional factors influence their use? Background: Feeding tube...
Article
Time to Rethink SBP. Do the Harms Outweigh the Benefits?
July 31, 2025
Clinical question: In the context of increasing antibiotic resistance and changing microbiology of Spontaneous Bacterial Peritonitis (SBP), does secondary SBP prophylaxis reduce the recurrence of SBP...
Article
IV Tenecteplase Before Thrombectomy in Stroke
July 31, 2025
Clinical question: Does IV Tenecteplase administered before endovascular thrombectomy lead to a higher likelihood of functional independence at 90 days compared to endovascular thrombectomy...
Article
Structured Exercise After Adjuvant Chemotherapy for Colon Cancer
July 31, 2025
Clinical question: Does a three-year structured exercise program, started after adjuvant chemotherapy, improve disease-free and overall survival in patients with resected colon cancer compared to...
Article
Antibiotic Treatment for 7 days is Noninferior to 14 days in Patients with Uncomplicated Bacteremia
June 2, 2025
Clinical question: Is seven days of antibiotic treatment for bloodstream infections noninferior to 14 days of treatment? Background: Bloodstream infections are very common, can originate from a...
Article
Restrictive Transfusion in MI May Lead to an Increase in 6-Month Mortality
June 2, 2025
Clinical question: How does a restrictive transfusion strategy (transfusion threshold of 7 to 8 g/dL) compare to a liberal transfusion strategy (transfusion threshold of 10 g/dL) in patients with...
Article
Efficacy of Adjuvant Corticosteroid Therapy for CAP Varied Significantly Based on C-Reactive Protein Concentrations
June 2, 2025
Clinical question: Can baseline C-reactive protein concentrations help identify which patients with community-acquired pneumonia (CAP) are most likely to benefit from adjuvant treatment with...
Article
Potential Post-Discharge Benefits of Continuing Metformin During Acute Hospitalization
June 2, 2025
Clinical question: Does the continuation of metformin during hospitalization result in fewer post-hospitalization complications, such as hypoglycemia or death? Background: Despite metformin’s...