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An Official Publication of
  • Clinical
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In the Literature

  • Article

    Oral Versus Extended-Release Injectable Naltrexone for Hospitalized Patients With AUD

    July 31, 2025

    Clinical question: Is there a difference in effectiveness between oral and injectable naltrexone at discharge for alcohol use disorder (AUD)? Background: AUD is common among inpatients, and most do...

  • Article

    IV Ferric Carboxymaltose in Heart Failure with Iron Deficiency

    July 31, 2025

    Clinical question: Does IV ferric carboxymaltose improve clinical outcomes in patients with heart failure (HF) and iron deficiency? Background: Iron deficiency affects up to half of patients with HF...

  • Article

    Feeding Tube Use Still Common in Hospitalized Older Adults with Dementia

    July 31, 2025

    Clinical question: How frequently are feeding tubes placed during hospitalization in older adults with dementia, and what patient or regional factors influence their use? Background: Feeding tube...

  • Article

    Time to Rethink SBP. Do the Harms Outweigh the Benefits?

    July 31, 2025

    Clinical question: In the context of increasing antibiotic resistance and changing microbiology of Spontaneous Bacterial Peritonitis (SBP), does secondary SBP prophylaxis reduce the recurrence of SBP...

  • Article

    IV Tenecteplase Before Thrombectomy in Stroke

    July 31, 2025

    Clinical question: Does IV Tenecteplase administered before endovascular thrombectomy lead to a higher likelihood of functional independence at 90 days compared to endovascular thrombectomy...

  • Article

    Structured Exercise After Adjuvant Chemotherapy for Colon Cancer

    July 31, 2025

    Clinical question: Does a three-year structured exercise program, started after adjuvant chemotherapy, improve disease-free and overall survival in patients with resected colon cancer compared to...

  • Article

    Antibiotic Treatment for 7 days is Noninferior to 14 days in Patients with Uncomplicated Bacteremia

    June 2, 2025

    Clinical question: Is seven days of antibiotic treatment for bloodstream infections noninferior to 14 days of treatment? Background: Bloodstream infections are very common, can originate from a...

  • Article

    Restrictive Transfusion in MI May Lead to an Increase in 6-Month Mortality

    June 2, 2025

    Clinical question: How does a restrictive transfusion strategy (transfusion threshold of 7 to 8 g/dL) compare to a liberal transfusion strategy (transfusion threshold of 10 g/dL) in patients with...

  • Article

    Efficacy of Adjuvant Corticosteroid Therapy for CAP Varied Significantly Based on C-Reactive Protein Concentrations

    June 2, 2025

    Clinical question: Can baseline C-reactive protein concentrations help identify which patients with community-acquired pneumonia (CAP) are most likely to benefit from adjuvant treatment with...

  • Article

    Potential Post-Discharge Benefits of Continuing Metformin During Acute Hospitalization

    June 2, 2025

    Clinical question: Does the continuation of metformin during hospitalization result in fewer post-hospitalization complications, such as hypoglycemia or death? Background: Despite metformin’s...

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