Article
Therapeutic-Dose Anticoagulation Shortened the Duration of ACS in Sickle Cell Disease Without Increasing Major Bleeding Risk
September 3, 2025
Clinical question: Does therapeutic-dose anticoagulation, compared to prophylactic dosing, improve clinical outcomes in adults with sickle cell disease hospitalized for acute chest syndrome...
Article
Hospital-Initiated MAUD: Oral and Extended-Release Naltrexone are Similarly Effective in Reducing Alcohol Use
September 3, 2025
Clinical question: Is there a difference in alcohol consumption between the oral and extended-release formulations of naltrexone when initiated in the hospital for patients with alcohol use disorder...
Article
Competencies for Those Who Coach Physicians: A Modified Delphi Study
September 3, 2025
Clinical question: What competencies are essential for coaching physicians effectively? Background: Physician coaching is founded on a supportive approach that empowers individuals and organizations...
Article
As-Needed BP Medication and Increased Adverse Outcomes in VA Hospitals
September 3, 2025
Clinical question: What are the adverse effects of as-needed BP medication on asymptomatic hypertension in hospitalized patients at risk of ischemic events due to high cardiovascular disease...
Article
Equivalent Mortality Regardless of Decision to Admit Versus Not to Admit in the 30 Days After an Index ED Visit
September 3, 2025
Clinical question: Do patients who are admitted to the hospital benefit from hospitalization, especially when the likelihood a given patient is admitted is highly dependent on the relative propensity...
Article
GPT-4 Assistance for Improvement of Physician Performance on Patient Care Tasks: A Randomized Controlled Trial
September 3, 2025
Clinical question: Does large language model (LLM) assistance improve physician performance on open-ended management reasoning tasks compared to conventional resources? Background: Management...
Article
Operative Versus Non-Operative Treatment of Acute Cholecystitis in Older Adults with Multiple Comorbidities–Advocating for Definitive Care
July 31, 2025
Clinical question: In patients 65 years and older, with multimorbidity, and presenting with acute cholecystitis, is operative treatment more efficacious than non-operative treatment? Background:...
Article
Prescribed In-Hospital Sodium Intake for ADHF: A Systematic Review and Meta-Analysis
July 31, 2025
Clinical question: Does prescribed oral and/or IV sodium supplementation plus loop diuretic administration improve outcomes for patients hospitalized with acute decompensated heart failure...
Article
Carvedilol Versus Propranolol for the Prevention of Decompensation and Mortality in Patients with Compensated and Decompensated Cirrhosis
July 31, 2025
Clinical question: Is carvedilol more effective than the classical non-selective beta-blockers (cNSBBs) propranolol or nadolol in preventing first decompensation and in reducing mortality in patients...
Article
Hospital Addiction Consultative Service Increases MOUD Initiation and Linkage to Follow-up After Discharge
July 31, 2025
Clinical question: Does an addiction-focused consult service increase medications for opioid use disorder (MOUD) initiation during inpatient hospitalization and connect patients to follow-up care...