Article
Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes
August 1, 2024
Clinical question: Is the treatment strategy with ticagrelor superior to prasugrel in acute coronary syndrome (ACS) with planned invasive evaluation at one year? Background: Dual antiplatelet...
Article
IV Sodium Thiosulphate for Calciphylaxis of CKD: A Systematic Review and Meta-analysis
August 1, 2024
Clinical question: Does IV sodium thiosulphate improve skin lesions and survival in patients with chronic kidney disease (CKD) experiencing calciphylaxis? Background: Calciphylaxis, also called...
Article
Maximizing Oral Iron Supplementation Absorption in Women
August 1, 2024
Clinical question: Is oral iron supplementation absorption influenced by the timing and/or nutritional elements concurrently consumed in healthy iron-deficient women? Background: Current guidelines...
Article
Frequent PT in Hospital Increases Home Discharge for Pneumonia Patients
June 3, 2024
Clinical question: Does increased frequency of physical therapy (PT) for hospitalized pneumonia patients affect their discharge to home versus to a post-acute care facility? Background: Each year,...
Article
Elevated fibrinogen and D-dimer relative to C-reactive protein linked to cognitive deficits post-COVID-19 hospitalization
June 3, 2024
Clinical question: Are acute blood biomarker profiles predictive of cognitive deficits following COVID-19 hospitalizations? Background: Cognitive deficits have been observed in many patients after...
Article
Liberal transfusion strategy in acute myocardial infarction patients with anemia not shown to significantly reduce recurrent MI or death
June 3, 2024
Clinical question: What should be the transfusion target for patients hospitalized for myocardial infarction (MI) with anemia? Background: Data on the optimal transfusion target for patients with MI...
Article
High-sensitivity versus conventional troponin in assessing PE risk
June 3, 2024
Clinical question: Is high-sensitivity cardiac troponin I (hs-cTnI) better at predicting outcomes for hemodynamically stable pulmonary embolism (PE) than conventional cardiac troponin I...
Article
Limited utility in using NT-proBNP rather than functional capacity to estimate risk of perioperative MACE
June 3, 2024
Clinical question: Does adding N-terminal pro–B-type natriuretic peptide (NT-proBNP) to clinical risk scores provide a better estimate of the risk of major adverse cardiac events (MACE) among...
Article
Semaglutide reduces major adverse cardiovascular events by 20% in patients with cardiovascular disease
June 3, 2024
Clinical question: Does semaglutide reduce cardiovascular events in non-diabetics with cardiovascular disease? Background: While glucagon-like peptide-1 (GLP-1) agonists reduce cardiovascular events...
Article
Comparing in-hospital adverse events in elderly postoperative delirium patients: haloperidol versus atypical antipsychotics
June 3, 2024
Clinical question: Are in-hospital adverse events worse in post-operative delirium patients treated with haloperidol compared to atypical antipsychotics? Background: Post-operative delirium is...