Article
Safety of Diltiazem in Patients Taking Apixaban or Rivaroxaban
March 4, 2025
Clinical question: Does diltiazem increase the risk of major bleeding in patients on apixaban or rivaroxaban? Background: Diltiazem is a potent CYP3A4 inhibitor and a mild P-glycoprotein inhibitor....
Article
Semaglutide Decreases Risk of Kidney Failure, Worsening of Kidney Disease, and Kidney-Related or Cardiovascular Death
March 4, 2025
Clinical question: Does treatment with semaglutide in patients with chronic kidney disease (CKD) and diabetes mellitus (DM) type II reduce the risk of kidney failure, progression of chronic kidney...
Article
Understanding the Inflation Reduction Act’s Impact on Prescription Drug Costs
February 3, 2025
Prescription drug costs in the U.S. are among the highest in the world, surpassing those in other high-income nations by more than two and a half times. In 2023, the U.S. healthcare system’s total...
Article
Inhaled Amikacin in the First 72 Hours of Mechanical Ventilation Reduced the Incidence of VAP
January 1, 2025
Clinical question: Does inhaled amikacin reduce the incidence of ventilator-associated pneumonia (VAP) in critically ill patients? Background: VAP is a common and serious complication in patients on...
Article
90-Day Mortality Among Septic Patients Given Piperacillin-Tazobactam Versus Cefepime
January 1, 2025
Clinical question: In patients with undifferentiated sepsis without an indication for anaerobic coverage, is there increased mortality with the combined use of vancomycin/piperacillin-tazobactam...
Article
Hydrocortisone Plus Fludrocortisone for CAP-Related Septic Shock
January 1, 2025
Clinical question: Does hydrocortisone and fludrocortisone reduce all-cause mortality among patients with septic shock due to community-acquired pneumonia (CAP)? Background: A meta-analysis of 17...
Article
Empagliflozin After Acute Myocardial Infarction (EMPACT-MI)
January 1, 2025
Clinical question: Does starting empagliflozin for patients with acute myocardial infarction (AMI) and new onset systolic heart failure (HF) or congestive symptoms reduce the risk of first...
Article
Illicit Medetomidine Use with Fentanyl
January 1, 2025
Medetomidine is a non-opioid veterinary anesthetic drug and a synthetic alpha-2-adrenoceptor agonist that is not approved for human use. Increasingly, it’s being used with illicitly manufactured...
Early Switch to Oral Antimicrobial Therapy for Staphylococcus aureus Bacteremia
November 1, 2024
Dr. Toy Clinical question: Is an early switch to oral antimicrobial therapy in low-risk Staphylococcus aureus bloodstream infection non-inferior to standard intravenous antimicrobial...
Article
GLP-1 RA Use is Associated with Increased Residual Gastric Contents in Appropriately Fasted Patients Before Elective Procedures
November 1, 2024
Drr. Taylor Clinical question: Does Glucagon-like Peptide-1 Receptor Agonist (GLP-1 RA) use lead to an increased risk of aspiration in patients undergoing anesthesia for elective...