Article
90-Day Mortality Among Septic Patients Given Piperacillin-Tazobactam Versus Cefepime
January 1, 2025
Clinical question: In patients with undifferentiated sepsis without an indication for anaerobic coverage, is there increased mortality with the combined use of vancomycin/piperacillin-tazobactam...
Article
Hydrocortisone Plus Fludrocortisone for CAP-Related Septic Shock
January 1, 2025
Clinical question: Does hydrocortisone and fludrocortisone reduce all-cause mortality among patients with septic shock due to community-acquired pneumonia (CAP)? Background: A meta-analysis of 17...
Article
Empagliflozin After Acute Myocardial Infarction (EMPACT-MI)
January 1, 2025
Clinical question: Does starting empagliflozin for patients with acute myocardial infarction (AMI) and new onset systolic heart failure (HF) or congestive symptoms reduce the risk of first...
Article
Illicit Medetomidine Use with Fentanyl
January 1, 2025
Medetomidine is a non-opioid veterinary anesthetic drug and a synthetic alpha-2-adrenoceptor agonist that is not approved for human use. Increasingly, it’s being used with illicitly manufactured...
Early Switch to Oral Antimicrobial Therapy for Staphylococcus aureus Bacteremia
November 1, 2024
Dr. Toy Clinical question: Is an early switch to oral antimicrobial therapy in low-risk Staphylococcus aureus bloodstream infection non-inferior to standard intravenous antimicrobial...
Article
GLP-1 RA Use is Associated with Increased Residual Gastric Contents in Appropriately Fasted Patients Before Elective Procedures
November 1, 2024
Drr. Taylor Clinical question: Does Glucagon-like Peptide-1 Receptor Agonist (GLP-1 RA) use lead to an increased risk of aspiration in patients undergoing anesthesia for elective...
Article
Opioid Prescribing and Outcomes in Patients with SCD Post-2016 CDC Guideline
November 1, 2024
Dr. Klubnick Clinical question: Did the 2016 U.S. Centers for Disease Control and Prevention (CDC) guideline for prescribing opioids for chronic pain change opioid prescribing practices and...
Article
Early Switch from IV to Oral Antibiotics for Uncomplicated Gram-Negative Bacteremia
November 1, 2024
Dr. Shindo Clinical question: Is there a mortality difference between early transition to oral antibiotics versus prolonged intravenous antibiotics in uncomplicated gram-negative...
Article
SGLT-2 inhibitors May Decrease Recurrent Gout Flares in Patients with Type 2 diabetes
May 1, 2024
Dr. Bernal Clinical question: Do SGLT-2 inhibitors decrease gout flares in patients with type 2 diabetes and a known history of gout? Background: Sodium–glucose cotransporter-2 inhibitors...
Article
Semaglutide in Patients with HFpEF and Obesity
May 1, 2024
Dr. Cepeda Mora Clinical question: Is semaglutide an effective heart failure treatment in patients with heart failure with preserved ejection fraction (HFpEF) and obesity? Background: HFpEF is...