Article
Beyond the Med List
February 2, 2026
I still remember one of my first nights on service as a new hospitalist nearly 14 years ago. A frail elderly man had just arrived from the emergency department with congestive heart failure. His...
Article
Oral Anticoagulation and Risk of Adverse Clinical Outcomes in VTE
February 2, 2026
CLINICAL QUESTION: How do the three most prescribed oral anticoagulants compare in regard to venous thromboembolism (VTE) recurrence, prevention, and major bleeding? BACKGROUND: Oral anticoagulants...
Article
Treating Cannabinoid Hyperemesis Syndrome in the Era of Cannabis Legalization
January 5, 2026
Cannabinoid hyperemesis syndrome (CHS) is a condition in which patients experience abdominal pain, nausea, and persistent vomiting following prolonged and heavy cannabis use. With the recent...
Article
Dexamethasone Non-Inferior to Prednisone or Prednisolone for Treatment of Pediatric Asthma Exacerbations
January 5, 2026
CLINICAL QUESTION: How does dexamethasone compare to prednisone or prednisolone when used to treat pediatric asthma exacerbations? BACKGROUND: Historically, the standard of care steroid choice for...
Article
Nirsevimab Effectively Reduces RSV Infection and Hospitalizations
January 5, 2026
CLINICAL QUESTION: How effective is nirsevimab at preventing respiratory syncytial virus (RSV) lower respiratory tract disease (LRTD), hospitalizations related to RSV, and any RSV...
Article
Less May Be More: Rethinking Antibiotic Use in Tracheostomized Children
January 5, 2026
CLINICAL QUESTION: Among hospitalized children with tracheostomies who develop respiratory symptoms (tracheobronchitis and nonspecific respiratory episodes), what is the pattern of antibiotic use,...
Article
Role of Ponsegromab in Treating Malignancy-Related Cachexia
December 1, 2025
CLINICAL QUESTION: Does treatment with ponsegromab, a monoclonal antibody inhibiting growth differentiation factor 15 (GDF-15), improve weight gain in patients with malignancy? BACKGROUND: Patients...
Article
Inebilizumab Can Treat IgG4-Related Disease
December 1, 2025
CLINICAL QUESTION: Is inebilizumab a safe and effective treatment option for IgG4-related disease? BACKGROUND: Treatment for IgG4-related disease flares currently involves glucocorticoid use and...
Article
Extended Reduced-Dose Apixaban for Treatment of VTE in Cancer Patients
December 1, 2025
CLINICAL QUESTION: Following full-dose treatment for six months, is reduced-dose apixaban noninferior to full-dose apixaban for the prevention of further recurrence of venous thromboembolism (VTE) in...
Article
Timely Cessation of PPIs in Critically Ill Patients is Associated with Mortality and Morbidity Reduction
November 3, 2025
CLINICAL QUESTION: Does the timely cessation of proton pump inhibitors (PPIs) in critically ill patients impact morbidity and mortality compared to those who continue PPI therapy? BACKGROUND: PPIs...