Article
Outpatient COVID-19 therapeutics reduce hospitalization and mortality
February 10, 2022
Matching the right patient to the right therapeutic at the right time In late 2021 and early 2022, the Food and Drug Administration (FDA) granted emergency use authorizations (EUAs) for the...
Article
To treat or not to treat: interpreting syphilis serologies
February 3, 2022
Case A 32-year-old man with history of intravenous heroin use presents to the emergency department (ED) for fevers and redness with purulence over the left forearm. He is started on IV vancomycin...
Article
Can I use DOAC in a patient with renal disease?
February 3, 2022
Case A 76-year-old man is diagnosed with non-valvular atrial fibrillation. His comorbid conditions are hypertension, diabetes complicated by neuropathy, and chronic kidney disease stage 3. His...
Article
A proposed scoring system to assess COVID-19-induced coagulopathy and stratification of patients for anticoagulation therapy based on risk categories
February 3, 2022
Clinical question: Can a proposed new scoring system triage and assess risk in COVID-19 patients with coagulopathy? Dr. Ajala Background: COVID-19-induced coagulopathy (CIC), marked...
Article
Direct oral anticoagulants may be safe in cancer-related venous thromboembolisms, but use caution with gastrointestinal malignancies
February 3, 2022
Clinical question: Are direct oral anticoagulants (DOACs) a suitable alternative to low molecular weight heparin (LMWH) for treatment of venous thromboembolism (VTE) in patients with underlying...
Article
Breakthrough infection in COVID-19-vaccinated health care workers is associated with lower levels of neutralizing antibodies but less severe disease
February 3, 2022
Clinical question: How frequent are breakthrough infections in health care workers fully vaccinated against COVID-19, and how does vaccination correlate with immune response and infectivity? ...
Article
Aspirin increases the risk of clinically significant gastrointestinal bleeding in older persons
February 3, 2022
Clinical question: Does aspirin impact the risk of clinically significant gastrointestinal (GI) bleeding compared with placebo in community-dwelling older persons (aged >/= 70 years)? Dr....
Article
Advocating for a patient-based approach to decisions of gastrostomy-tube placement in patients with dementia
February 3, 2022
Clinical question: Should providers universally not recommend feeding tubes in patients with dementia and poor oral intake? Dr. Day Background: The natural progression of advancing dementia...
Article
Hypertonic saline solution with furosemide infusion may be beneficial in fluid overload in patients with reduced ejection fraction
February 3, 2022
Clinical question: Is simultaneous infusion of hypertonic saline and IV furosemide more efficacious than IV furosemide alone in patients with fluid overload? Dr. Obisesan Background:...
Article
Most patients meeting sepsis criteria in the emergency department do not have a sepsis diagnosis
February 3, 2022
Dr. Taghvaei Clinical question: What percentage of patients treated for sepsis in the ED are diagnosed with sepsis at discharge? Background: Sepsis is a leading cause of death around the world...