Background: Sepsis is responsible for an increasingly disproportionate fraction of health care burden. Delays in diagnosis of sepsis are associated with worse outcomes.
Study design: Retrospective observational study.
Setting: Premier Healthcare database, including 20% of U.S. private/academic hospitals.
Synopsis: With use of the Premier Healthcare database, researchers identified 2,566,689 cases of sepsis using ICD-9 and MS-DRG codes between Jan. 1, 2010, and Sept. 30, 2016. Increasing severity of sepsis was associated with increasing mortality and cost, but there was a large discrepancy in cost in patients with sepsis present at admission versus those without it at admission ($18,023 vs. $51,022) and was associated with increases in both mean hospital length of stay and mortality rate across all levels of sepsis severity.
Bottom line: Early identification of sepsis (at admission vs. later in the stay) may be important as a factor to reduce its overall burden on the health care system.
Citation: Paoli CJ et al. Epidemiology and costs of sepsis in the United States – An analysis based on timing of diagnosis and severity level..
Dr. Ho is an assistant professor of medicine in the division of general and hospital medicine at UT Health San Antonio and a hospitalist at South Texas Veterans Health Care System.