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In the Literature: January 2010

In This Edition

Literature at a Glance

A guide to this month’s studies

  • Resident duty hours and ICU patient outcomes
  • Effect of ER boarding on patient outcomes
  • ED voicemail signout of patients
  • Adequacy of patient signouts
  • D-dimer use in patients with low suspicion of pulmonary embolism
  • Patient involvement in medication reconciliation
  • Effects of on-screen reminders on outcomes

Decreased ICU Duty Hours Does Not Affect Patient Mortality

Clinical question: Does the reduction in work hours for residents affect mortality in medical and surgical ICUs?

Background: A reduction in work hours for residents was enforced in July 2003. Several prior studies using administrative or claims data did not show an association of the reduced work hours for residents with mortality in teaching hospitals when compared with nonteaching hospitals.

Study design: Observational retrospective registry cohort.

Setting: Twelve academic, 12 community, and 16 nonteaching hospitals in the U.S.

Synopsis: Data from 230,151 patients were extracted as post-hoc analysis from a voluntary clinical registry that uses a well-validated severity-of-illness scoring system. The exposure was defined as date of admission to ICU within two years before and after the reform. Hospitals were categorized as academic, community with residents, or nonteaching. Sophisticated statistical analyses were performed, including interaction terms for teaching status and time. To test the effect the reduced work hours had on mortality, the mortality trends of academic hospitals and community hospitals with residents were compared with the baseline trend of nonteaching hospitals. After risk adjustments, all hospitals had improved in-hospital and ICU mortality after the reform. None of the statistical improvements were significantly different.

Study limitations include the selection bias, as only highly motivated hospitals participating in the registry were included, and misclassification bias, as not all hospitals implemented the reform at the same time. Nevertheless, this study supports the consistent literature on the topic and adds a more robust assessment of severity of illness.

Bottom line: The restriction on resident duty hours does not appear to affect patient mortality.

Citation: Prasad M, Iwashyna TJ, Christie JD, et al. Effect of work-hours regulations on intensive care unit mortality in United States teaching hospitals. Crit Care Med. 2009;37(9):2564-2569.

Clinical Shorts

NT-PRO-BNP LEVELS ELEVATED IN PLEURAL FLUID FROM HEART FAILURE

Diagnostic analysis showed NT-pro-BNP in pleural fluid most accurate (area under the curve 0.96) at diagnosing pleural fluid from heart failure with a cutoff value of 1,300 pg/ml.

Citation: Porcel JM, Martínez-Alonso M, Cao G, Bielsa S, Sopena A, Esquerda A. Biomarkers of heart failure in pleural fluid. Chest. 2009;136(3):671-677.

TRANSFUSIONS MIGHT IMPROVE OUTCOMES IN ACUTE DECOMPENSATED HEART FAILURE

Employing propensity scores, this prospective, observational analysis suggests that anemic patients with clinically diagnosed acute decompensated congestive heart failure might benefit from blood transfusions. Prospective, controlled, randomized analyses are required.

Citation: Garty M, Cohen E, Zuchenko A, et al. Blood transfusion for acute decompensated failure—friend or foe? Am Heart J. 2009;158(4):653-658.

ROLE OF CT COLONOGRAPHY REMAINS UNCERTAIN

A prospective assessment of CT colonography (CTC) operating characteristics suggests it is an inefficient and cost-ineffective triage tool when following up positive fecal occult blood testing. However, patients preferred CTC over colonoscopy.

Citation: Liedenbaum MH, van Rijn AF, de Vries AH, et al. Using CT colonography as a triage technique after a positive faecal occult blood test in colorectal cancer screening. Gut. 2009;58(9):1242-1249.

IN VTE EVALUATION IN THE ED, D-DIMER USE AND SUBSEQUENT IMAGING ARE RARELY USED IN ACCORDANCE WITH EVIDENCE-BASED GUIDELINES

In this retrospective review at one ED, 48% of patients with an elevated D-dimer did not undergo follow-up imaging, and 14% of those with a negative result had subsequent imaging.

Citation: Tiesmann NA, Cheung PT, Frazee B. Is the ordering of imaging for suspected venous thromboembolism consistent with D-dimer result? Ann Emerg Med. 2009;54(3):442-446.

  • 1

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    Growth Spurt

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    Step-by-Step Medicine

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    December 23, 2009

  • In the Literature: The Latest Research You Need to Know

    December 23, 2009

  • Congress Gets Defensive with Medicare Payments

    December 23, 2009

  • Project BOOST Expansion Planned

    December 23, 2009

  • Medical Journals Make Proactive Move

    December 16, 2009

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