Article
Absence of CSF Pleocytosis Prevalent in Encephalitis and Can Delay Empiric Treatment
March 4, 2025
Clinical question: Is there a difference in clinical factors and outcomes among patients with new-onset encephalitis based on whether their initial cerebrospinal fluid (CSF) studies demonstrate the...
Article
Metronidazole-Related Encephalopathy and Neuropathy Associated with IV Administration, Liver Cirrhosis, and CKD
January 1, 2025
Clinical question: What is the prevalence of metronidazole-related neurologic adverse events and what are the risk factors associated with these events? Background: A 2021 study reported neurologic...
Article
Clinical Risk Score Predicts Arterial Thrombosis in Survivors of Intracranial Hemorrhage
January 1, 2025
Clinical question: Among survivors of hemorrhagic stroke, who is at high long-term risk of arterial thrombosis? Background: Patients who survive intracerebral hemorrhage (ICH) are at increased risk...
Article
Piperacillin-tazobactam Doesn’t Increase Risk of AKI Compared to Cefepime
May 1, 2024
Dr. Rhodes Clinical question: Do piperacillin-tazobactam and cefepime have similar risks of acute kidney injury (AKI)? Background: Observational studies have shown an association between...
Article
Back Off the Baclofen: Increased Risk of Encephalopathy
May 1, 2024
Dr. Sata Clinical question: Compared to other muscle relaxants, does baclofen increase the risk of encephalopathy? Background: Baclofen is a GABAergic muscle relaxant that is useful for patients...
Article
DAPT Non-inferior to Alteplase for Minor AIS
October 2, 2023
Clinical question: Is dual antiplatelet therapy (DAPT) non-inferior to intravenous (IV) thrombolysis in patients with minor non-disabling acute ischemic strokes (AIS)? Dr....
Article
Endovascular Therapy for Acute Stroke with a Large Ischemic Region
April 3, 2023
Dr. Arobelidze Clinical question: Does endovascular therapy for acute stroke with a large ischemic region have better functional outcomes compared to medical therapy alone without increasing the...
Article
Negative initial CSF studies in HSV encephalitis portend worse neurologic outcomes
May 2, 2022
Clinical question: Does delay in diagnosis of herpes simplex virus (HSV) encephalitis due to negative initial cerebrospinal fluid (CSF) studies affect neurologic outcomes? Dr....
Article
A 12-month implantable loop recorder detects more atrial fibrillation than 30-day external monitoring after ischemic stroke
January 7, 2022
Dr. Winget Clinical question: In patients with recent ischemic stroke, does monitoring for 12 months with an implantable loop recorder (ILR) detect more atrial fibrillation (AF) than 30 days with...
News
Epilepsy linked to 1.5-fold higher COVID-19 mortality in hospital
December 14, 2021
Findings suggest higher risk although researchers haven’t adjusted findings for confounders yet.