Article
Effects of Semaglutide on CKD in Patients with Type 2 Diabetes: the FLOW Trial
April 1, 2025
Clinical question: Does treatment with semaglutide in patients with type 2 diabetes and chronic kidney disease (CKD) prevent the progression of CKD or death from kidney and cardiovascular...
Article
Renal Function and Decongestion with ADHF: the ADVOR Trial
March 4, 2025
Clinical question: Does acetazolamide enhance loop diuretic effect in patients with acute decompensated heart failure (ADHF) and how does this combination affect renal function? Background: Nearly...
Article
Semaglutide Decreases Risk of Kidney Failure, Worsening of Kidney Disease, and Kidney-Related or Cardiovascular Death
March 4, 2025
Clinical question: Does treatment with semaglutide in patients with chronic kidney disease (CKD) and diabetes mellitus (DM) type II reduce the risk of kidney failure, progression of chronic kidney...
Article
Metronidazole-Related Encephalopathy and Neuropathy Associated with IV Administration, Liver Cirrhosis, and CKD
January 1, 2025
Clinical question: What is the prevalence of metronidazole-related neurologic adverse events and what are the risk factors associated with these events? Background: A 2021 study reported neurologic...
Article
Incidence of Colorectal Cancer in Patients Diagnosed with PLA
November 1, 2024
Dr. Katsnelson Clinical question: Is there an association between pyogenic liver abscess (PLA) and subsequent incidence of diagnosed colorectal cancer (CRC) and if so, should early screening for...
Article
To RAASi or Not to RAASi, That is the Question
October 1, 2024
Clinical question: Should angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARBs) be discontinued or continued in advanced chronic kidney disease (CKD)...
Article
ACLF Grade 3 Predicts Risk of Respiratory Failure with Terlipressin Use
October 1, 2024
Ms. Boyle Clinical question: Which risk factors predict new-onset respiratory failure during terlipressin use for the treatment of patients with rapidly deteriorating kidney function attributed...
Article
IV Sodium Thiosulphate for Calciphylaxis of CKD: A Systematic Review and Meta-analysis
August 1, 2024
Clinical question: Does IV sodium thiosulphate improve skin lesions and survival in patients with chronic kidney disease (CKD) experiencing calciphylaxis? Background: Calciphylaxis, also called...
Article
DOACs Versus Warfarin Across the Spectrum of Kidney Function
April 1, 2024
Clinical question: How safe are direct oral anticoagulants (DOACs) to use in kidney dysfunction? Background: DOACs are increasingly being used in patients with kidney dysfunction. DOACs are cleared,...
Article
Associations of Apixaban Dose with Safety and Effectiveness Outcomes in Patients with Atrial Fibrillation and Severe CKD
April 1, 2024
Clinical question: Is the use of standard-dose apixaban based on creatinine criteria placing patients at higher risk of bleeding? Background: The U.S. Food and Drug Administration recommends...