Article
Continuous Versus Intermittent Infusion of β-Lactam Antibiotics in Critically Ill Patients with Sepsis
May 1, 2025
Clinical question: Does continuous infusion of β-lactam antibiotics reduce 90-day mortality compared with intermittent infusion in critically ill patients with sepsis? Background: Sepsis, a...
Article
90-Day Mortality Among Septic Patients Given Piperacillin-Tazobactam Versus Cefepime
January 1, 2025
Clinical question: In patients with undifferentiated sepsis without an indication for anaerobic coverage, is there increased mortality with the combined use of vancomycin/piperacillin-tazobactam...
Article
Hydrocortisone Plus Fludrocortisone for CAP-Related Septic Shock
January 1, 2025
Clinical question: Does hydrocortisone and fludrocortisone reduce all-cause mortality among patients with septic shock due to community-acquired pneumonia (CAP)? Background: A meta-analysis of 17...
Article
Early Switch from IV to Oral Antibiotics for Uncomplicated Gram-Negative Bacteremia
November 1, 2024
Dr. Shindo Clinical question: Is there a mortality difference between early transition to oral antibiotics versus prolonged intravenous antibiotics in uncomplicated gram-negative...
Article
Diagnostic Stewardship in CAP with Syndromic Molecular Testing
November 1, 2024
Clinical question: Does syndromic polymerase chain reaction (PCR)-based testing of lower respiratory tract samples in patients hospitalized with community-acquired pneumonia (CAP) lead to faster...
Article
No Difference in Safety or Mortality with Restrictive Versus Liberal Fluid Resuscitation Strategy for Ongoing Resuscitation in ICU Patients with Septic Shock
August 1, 2024
Clinical question: Are there safety or mortality benefits to the use of a more restrictive versus liberal IV fluid strategy for ongoing IV fluid resuscitation in critically ill patients with septic...
Article
Pneumonia: Updates, Best Practices, and Controversies
July 1, 2024
In this clinically focused session, Dr. Joanna M Bonsall, associate professor at Emory University School of Medicine and hospitalist at Grady Memorial Hospital in Atlanta, discussed portions of the...
Article
Reliability of Admission Procalcitonin Testing for Capturing Bacteremia Across the Sepsis Spectrum
April 1, 2024
Clinical question: Can serum procalcitonin reliably detect bloodstream infections upon hospital admission? Background: Hospitalists frequently manage patients with bacteremia, which is often...
Article
Pitavastatin to Prevent Cardiovascular Disease in HIV Infection
April 1, 2024
Clinical question: Does pitavastatin decrease major adverse cardiovascular events (MACEs) in patients infected by the human immunodeficiency virus (HIV) who are on antiretroviral therapy (ART) and...
Article
Early Restrictive or Liberal Fluid Management for Sepsis-induced Hypotension
April 1, 2024
Clinical question: What’s the effect of restrictive versus liberal fluid resuscitation strategies in sepsis-induced hypotension on 90-day mortality? Background: Intravenous fluid resuscitation is...