Article
Safety of Diltiazem in Patients Taking Apixaban or Rivaroxaban
March 4, 2025
Clinical question: Does diltiazem increase the risk of major bleeding in patients on apixaban or rivaroxaban? Background: Diltiazem is a potent CYP3A4 inhibitor and a mild P-glycoprotein inhibitor....
Article
Semaglutide Decreases Risk of Kidney Failure, Worsening of Kidney Disease, and Kidney-Related or Cardiovascular Death
March 4, 2025
Clinical question: Does treatment with semaglutide in patients with chronic kidney disease (CKD) and diabetes mellitus (DM) type II reduce the risk of kidney failure, progression of chronic kidney...
Article
Absence of CSF Pleocytosis Prevalent in Encephalitis and Can Delay Empiric Treatment
March 4, 2025
Clinical question: Is there a difference in clinical factors and outcomes among patients with new-onset encephalitis based on whether their initial cerebrospinal fluid (CSF) studies demonstrate the...
Article
Efficacy of AI models in Detecting Clinical Deterioration
January 1, 2025
Clinical question: Can an artificial intelligence (AI) enabled intervention model reduce the risk of clinical deterioration and subsequent care escalation in hospitalized patients? Background:...
Article
Metronidazole-Related Encephalopathy and Neuropathy Associated with IV Administration, Liver Cirrhosis, and CKD
January 1, 2025
Clinical question: What is the prevalence of metronidazole-related neurologic adverse events and what are the risk factors associated with these events? Background: A 2021 study reported neurologic...
Article
Comparison of Hospital Mortality and Readmission Rates by Physician and Patient Sex
January 1, 2025
Clinical question: Are hospital mortality and readmission rates associated with physician sex, and do these associations vary by patient sex? Background: Prior studies indicate that physician...
Article
Inhaled Amikacin in the First 72 Hours of Mechanical Ventilation Reduced the Incidence of VAP
January 1, 2025
Clinical question: Does inhaled amikacin reduce the incidence of ventilator-associated pneumonia (VAP) in critically ill patients? Background: VAP is a common and serious complication in patients on...
Article
90-Day Mortality Among Septic Patients Given Piperacillin-Tazobactam Versus Cefepime
January 1, 2025
Clinical question: In patients with undifferentiated sepsis without an indication for anaerobic coverage, is there increased mortality with the combined use of vancomycin/piperacillin-tazobactam...
Article
Hydrocortisone Plus Fludrocortisone for CAP-Related Septic Shock
January 1, 2025
Clinical question: Does hydrocortisone and fludrocortisone reduce all-cause mortality among patients with septic shock due to community-acquired pneumonia (CAP)? Background: A meta-analysis of 17...
Article
Empagliflozin After Acute Myocardial Infarction (EMPACT-MI)
January 1, 2025
Clinical question: Does starting empagliflozin for patients with acute myocardial infarction (AMI) and new onset systolic heart failure (HF) or congestive symptoms reduce the risk of first...