Article
Anti-Xa Monitoring During Therapeutic LMWH Use Leads to Frequent Dose Changes Without Clear Evidence of Improved Clinical Outcomes
September 2, 2026
Clinical Question: In patients receiving therapeutic low-molecular-weight heparin (LMWH), does anti-Xa monitoring with subsequent dose adjustment improve bleeding or thrombotic outcomes? Background:...
Article
IV Iron Administration During Acute Infection Does Not Worsen Outcomes and Is Associated with Improved Survival and Hemoglobin Recovery
September 2, 2026
Clinical Question: In hospitalized adults with iron-deficiency anemia (IDA) and concurrent acute infection, does IV iron administration improve clinical outcomes or worsen the infection? Background:...
Article
Personalized Hemodynamic Resuscitation Using Capillary Refill Time
August 3, 2026
Clinical Question: Does personalized resuscitation improve outcomes in early septic shock when targeting capillary refill compared to usual care? Background: Resuscitation in early septic shock is...
Article
When Less is More: How to Provide Less Anticoagulant and Antiplatelet Treatment to Improve Outcomes
July 1, 2026
As hospitalists, we are often trained to err on the side of doing more, especially in the ways we have historically approached anticoagulation and antiplatelet therapies. Faced with the competing...
Article
Evaluation of Optimal Duration of DAPT After PCI When Stratified by Bleeding Risk
June 18, 2026
Mount Sinai Med-Lit Review Clinical question: What is the optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) with drug-eluting stent (DES) placement...
Article
Extended Low-Dose Apixaban After Provoked VTE Reduces Recurrence in Selected Patients
June 18, 2026
Mount Sinai Med-Lit Review Clinical question: Among patients with provoked venous thromboembolism (VTE) and ongoing risk factors, does extending anticoagulation with low-dose apixaban reduce...
Article
Response to Blood Culture Shortage Promotes High Value Care
May 1, 2026
Clinical question: Do diagnostic stewardship interventions in times of crisis lead to sustained change in blood-culture ordering practices? Background: It is estimated that a third of all blood...
Article
Anticoagulation and Antiplatelet Therapy in Patients with AF and Atherosclerosis
April 6, 2026
CLINICAL QUESTION: In patients with atherosclerotic disease and concurrent atrial fibrillation, does adding antiplatelet therapy to oral anticoagulation improve net clinical outcomes compared with...
Article
Octreotide LAR Reduced Transfusion Needs and Endoscopic Interventions in Angiodysplasia-Related Anemia
November 3, 2025
CLINICAL QUESTION: Does octreotide long-acting release (LAR) reduce transfusion requirements in patients with angiodysplasia-related anemia? BACKGROUND: Angiodysplasias frequently cause refractory...
Article
Therapeutic-Dose Anticoagulation Shortened the Duration of ACS in Sickle Cell Disease Without Increasing Major Bleeding Risk
September 3, 2025
Clinical question: Does therapeutic-dose anticoagulation, compared to prophylactic dosing, improve clinical outcomes in adults with sickle cell disease hospitalized for acute chest syndrome...