Article
Response to Blood Culture Shortage Promotes High Value Care
May 1, 2026
Clinical question: Do diagnostic stewardship interventions in times of crisis lead to sustained change in blood-culture ordering practices? Background: It is estimated that a third of all blood...
Article
Anticoagulation and Antiplatelet Therapy in Patients with AF and Atherosclerosis
April 6, 2026
CLINICAL QUESTION: In patients with atherosclerotic disease and concurrent atrial fibrillation, does adding antiplatelet therapy to oral anticoagulation improve net clinical outcomes compared with...
Article
Octreotide LAR Reduced Transfusion Needs and Endoscopic Interventions in Angiodysplasia-Related Anemia
November 3, 2025
CLINICAL QUESTION: Does octreotide long-acting release (LAR) reduce transfusion requirements in patients with angiodysplasia-related anemia? BACKGROUND: Angiodysplasias frequently cause refractory...
Article
Therapeutic-Dose Anticoagulation Shortened the Duration of ACS in Sickle Cell Disease Without Increasing Major Bleeding Risk
September 3, 2025
Clinical question: Does therapeutic-dose anticoagulation, compared to prophylactic dosing, improve clinical outcomes in adults with sickle cell disease hospitalized for acute chest syndrome...
Article
Antibiotic Treatment for 7 days is Noninferior to 14 days in Patients with Uncomplicated Bacteremia
June 2, 2025
Clinical question: Is seven days of antibiotic treatment for bloodstream infections noninferior to 14 days of treatment? Background: Bloodstream infections are very common, can originate from a...
Article
Restrictive Transfusion in MI May Lead to an Increase in 6-Month Mortality
June 2, 2025
Clinical question: How does a restrictive transfusion strategy (transfusion threshold of 7 to 8 g/dL) compare to a liberal transfusion strategy (transfusion threshold of 10 g/dL) in patients with...
Article
Should Hospitalists Throw Caution to the Wind? Overly Cautious Correction of Severe Hyponatremia May Lead to Greater Harm Than Good
June 2, 2025
Clinical question: Does the correction rate for hospitalized adults with severe hyponatremia correlate with mortality or length of stay? Background: Hyponatremia is a commonly encountered problem...
Article
Gram-Negative Bacteremia: Early Transition from IV to PO Antibiotic Therapy
March 4, 2025
Clinical question: What is the safety and efficacy of switching from IV to oral antibiotic therapy after three to five days in patients with gram-negative bacteremia? Background: Bacteremia is...
Article
Slower Correction of Sodium in Severe Hyponatremia is Associated with Increased Mortality and Length of Stay
March 4, 2025
Clinical question: Is the sodium correction rate in severe hyponatremia associated with mortality and length of stay? Background: Hyponatremia is commonly encountered in the hospital, with high...
Article
Interpretation of Serum Ammonia Level
December 2, 2024
A 77-year-old woman with a history of hepatitis C cirrhosis presents to the emergency department with 24 hours of progressive confusion and disorientation. The physical exam is notable for...