Article
Opioid Prescribing and Outcomes in Patients with SCD Post-2016 CDC Guideline
November 1, 2024
Dr. Klubnick Clinical question: Did the 2016 U.S. Centers for Disease Control and Prevention (CDC) guideline for prescribing opioids for chronic pain change opioid prescribing practices and...
Article
Early Switch from IV to Oral Antibiotics for Uncomplicated Gram-Negative Bacteremia
November 1, 2024
Dr. Shindo Clinical question: Is there a mortality difference between early transition to oral antibiotics versus prolonged intravenous antibiotics in uncomplicated gram-negative...
Article
SGLT-2 inhibitors May Decrease Recurrent Gout Flares in Patients with Type 2 diabetes
May 1, 2024
Dr. Bernal Clinical question: Do SGLT-2 inhibitors decrease gout flares in patients with type 2 diabetes and a known history of gout? Background: Sodium–glucose cotransporter-2 inhibitors...
Article
Semaglutide in Patients with HFpEF and Obesity
May 1, 2024
Dr. Cepeda Mora Clinical question: Is semaglutide an effective heart failure treatment in patients with heart failure with preserved ejection fraction (HFpEF) and obesity? Background: HFpEF is...
Article
Piperacillin-tazobactam Doesn’t Increase Risk of AKI Compared to Cefepime
May 1, 2024
Dr. Rhodes Clinical question: Do piperacillin-tazobactam and cefepime have similar risks of acute kidney injury (AKI)? Background: Observational studies have shown an association between...
Article
Back Off the Baclofen: Increased Risk of Encephalopathy
May 1, 2024
Dr. Sata Clinical question: Compared to other muscle relaxants, does baclofen increase the risk of encephalopathy? Background: Baclofen is a GABAergic muscle relaxant that is useful for patients...
Article
Can Pentoxifylline Improve Healing of Lower Extremity Ulcers?
May 1, 2024
Case The patient, Mr. D, has been experiencing swelling in his legs for several years, and seven months prior, he noticed that his skin had started to develop ulcers. He has class 3 obesity, type 2...
Article
Cefepime Versus Piperacillin-tazobactam in Adults Hospitalized with Acute Infection
April 1, 2024
Clinical question: Are there increased adverse outcomes with the utilization of cefepime or piperacillin-tazobactam? Background: Hospitalists frequently prescribe cefepime or piperacillin-tazobactam...
Article
Moderate-intensity Statin With Ezetimibe Combination Therapy Versus High-intensity Statin Monotherapy in Patients at Very High Risk of ASCVD
April 1, 2024
Clinical question: Can you use a moderate-intensity statin with ezetimibe combination therapy for very high-risk (VHR) patients with ASCVD? Background: The ACC/AHA guidelines recommend the use of...
Article
Aspirin or LMWH for Thromboprophylaxis After a Fracture
April 1, 2024
Clinical question: Can you use aspirin as a safe alternative to low-molecular-weight heparin (LMWH) for thromboprophylaxis in patients with an extremity fracture? Background: Many guidelines...