Article
Piperacillin-tazobactam Doesn’t Increase Risk of AKI Compared to Cefepime
May 1, 2024
Dr. Rhodes Clinical question: Do piperacillin-tazobactam and cefepime have similar risks of acute kidney injury (AKI)? Background: Observational studies have shown an association between...
Article
Back Off the Baclofen: Increased Risk of Encephalopathy
May 1, 2024
Dr. Sata Clinical question: Compared to other muscle relaxants, does baclofen increase the risk of encephalopathy? Background: Baclofen is a GABAergic muscle relaxant that is useful for patients...
Article
Can Pentoxifylline Improve Healing of Lower Extremity Ulcers?
May 1, 2024
Case The patient, Mr. D, has been experiencing swelling in his legs for several years, and seven months prior, he noticed that his skin had started to develop ulcers. He has class 3 obesity, type 2...
Article
Cefepime Versus Piperacillin-tazobactam in Adults Hospitalized with Acute Infection
April 1, 2024
Clinical question: Are there increased adverse outcomes with the utilization of cefepime or piperacillin-tazobactam? Background: Hospitalists frequently prescribe cefepime or piperacillin-tazobactam...
Article
Moderate-intensity Statin With Ezetimibe Combination Therapy Versus High-intensity Statin Monotherapy in Patients at Very High Risk of ASCVD
April 1, 2024
Clinical question: Can you use a moderate-intensity statin with ezetimibe combination therapy for very high-risk (VHR) patients with ASCVD? Background: The ACC/AHA guidelines recommend the use of...
Article
Aspirin or LMWH for Thromboprophylaxis After a Fracture
April 1, 2024
Clinical question: Can you use aspirin as a safe alternative to low-molecular-weight heparin (LMWH) for thromboprophylaxis in patients with an extremity fracture? Background: Many guidelines...
Article
No Clear Benefit to the Use of Haloperidol for ICU Delirium
February 1, 2024
Dr. Leventhal Clinical question: Does the use of haloperidol versus placebo for delirium in ICU patients improve mortality and increase the chance of hospital discharge at 90 days? Background:...
Article
Abatacept and Infliximab May Improve Mortality in Patients Hospitalized with COVID-19 Pneumonia
February 1, 2024
Dr. Rose Clinical question: What immunomodulatory drugs should we use in hospitalized patients with COVID-19 in addition to corticosteroids? Background: Inflammation is a key driver of morbidity...
Article
Clinical Update: RSV Vaccines for Adults
December 7, 2023
Respiratory syncytial virus (RSV) is a common seasonal virus that can cause serious illness in children and adults alike. It was first isolated in a group of chimpanzees in 1956 and was originally...
Article
Questions Remain About Nirsevimab’s Impact
November 16, 2023
The new monoclonal antibody nirsevimab may radically change incidence and outcomes for respiratory syncytial virus (RSV) infections in young pediatric patients, especially when combined with the...