Article
Role of Ponsegromab in Treating Malignancy-Related Cachexia
December 1, 2025
CLINICAL QUESTION: Does treatment with ponsegromab, a monoclonal antibody inhibiting growth differentiation factor 15 (GDF-15), improve weight gain in patients with malignancy? BACKGROUND: Patients...
Article
Inebilizumab Can Treat IgG4-Related Disease
December 1, 2025
CLINICAL QUESTION: Is inebilizumab a safe and effective treatment option for IgG4-related disease? BACKGROUND: Treatment for IgG4-related disease flares currently involves glucocorticoid use and...
Article
Extended Reduced-Dose Apixaban for Treatment of VTE in Cancer Patients
December 1, 2025
CLINICAL QUESTION: Following full-dose treatment for six months, is reduced-dose apixaban noninferior to full-dose apixaban for the prevention of further recurrence of venous thromboembolism (VTE) in...
Article
Timely Cessation of PPIs in Critically Ill Patients is Associated with Mortality and Morbidity Reduction
November 3, 2025
CLINICAL QUESTION: Does the timely cessation of proton pump inhibitors (PPIs) in critically ill patients impact morbidity and mortality compared to those who continue PPI therapy? BACKGROUND: PPIs...
Article
History of Antibiotic Stewardship
October 1, 2025
Antibiotic stewardship—the coordinated effort to optimize antimicrobial use—is integral to hospital medicine, though its origins extend much earlier than contemporary clinical programs...
Article
Perioperative Medication Management Controversies
July 1, 2025
The session began with Alana Sigmund, MD, SFHM, medical director for arthroplasty at the Hospital for Special Surgery in New York, addressing the complex issue of perioperative medication management,...
Article
Antibiotic Treatment for 7 days is Noninferior to 14 days in Patients with Uncomplicated Bacteremia
June 2, 2025
Clinical question: Is seven days of antibiotic treatment for bloodstream infections noninferior to 14 days of treatment? Background: Bloodstream infections are very common, can originate from a...
Article
Efficacy of Adjuvant Corticosteroid Therapy for CAP Varied Significantly Based on C-Reactive Protein Concentrations
June 2, 2025
Clinical question: Can baseline C-reactive protein concentrations help identify which patients with community-acquired pneumonia (CAP) are most likely to benefit from adjuvant treatment with...
Article
Potential Post-Discharge Benefits of Continuing Metformin During Acute Hospitalization
June 2, 2025
Clinical question: Does the continuation of metformin during hospitalization result in fewer post-hospitalization complications, such as hypoglycemia or death? Background: Despite metformin’s...
Article
Health Systems and Prescribers Can Favor a Single Triple-Therapy Inhaler in COPD that Both Improves Patient Outcomes and Reduces the Climate Impacts of Healthcare
June 2, 2025
Clinical question: How do the two available (U.S. market) single triple-therapy inhalers compare in terms of safety and efficacy for patients with chronic obstructive pulmonary disease (COPD), with...