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An Official Publication of
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Pharmacology

  • Article

    Perioperative Medication Management Controversies

    July 1, 2025

    The session began with Alana Sigmund, MD, SFHM, medical director for arthroplasty at the Hospital for Special Surgery in New York, addressing the complex issue of perioperative medication management,...

  • Article

    Antibiotic Treatment for 7 days is Noninferior to 14 days in Patients with Uncomplicated Bacteremia

    June 2, 2025

    Clinical question: Is seven days of antibiotic treatment for bloodstream infections noninferior to 14 days of treatment? Background: Bloodstream infections are very common, can originate from a...

  • Article

    Efficacy of Adjuvant Corticosteroid Therapy for CAP Varied Significantly Based on C-Reactive Protein Concentrations

    June 2, 2025

    Clinical question: Can baseline C-reactive protein concentrations help identify which patients with community-acquired pneumonia (CAP) are most likely to benefit from adjuvant treatment with...

  • Article

    Potential Post-Discharge Benefits of Continuing Metformin During Acute Hospitalization

    June 2, 2025

    Clinical question: Does the continuation of metformin during hospitalization result in fewer post-hospitalization complications, such as hypoglycemia or death? Background: Despite metformin’s...

  • Article

    Health Systems and Prescribers Can Favor a Single Triple-Therapy Inhaler in COPD that Both Improves Patient Outcomes and Reduces the Climate Impacts of Healthcare

    June 2, 2025

    Clinical question: How do the two available (U.S. market) single triple-therapy inhalers compare in terms of safety and efficacy for patients with chronic obstructive pulmonary disease (COPD), with...

  • Article

    Sex Disparities in Opioid Prescription Practices on a Hospital Medicine Service

    April 1, 2025

    Clinical question: Does patient sex influence opioid prescription patterns during hospitalization and at discharge on general medicine services? Background: Clinicians may have sex- and gender-based...

  • Article

    Comparative Effectiveness and Safety of Apixaban, Rivaroxaban, and Warfarin in Patients with Cirrhosis and AF

    March 4, 2025

    Clinical question: What is the effectiveness and safety of apixaban, rivaroxaban, and warfarin in patients with cirrhosis and atrial fibrillation? Background: The use of direct oral anticoagulants...

  • Article

    Gabapentinoid Use Associated with Increased Risk of Severe Exacerbations in Patientswith COPD

    March 4, 2025

    Clinical question: Does gabapentinoid use increase the risk of severe exacerbation in patients with chronic obstructive pulmonary disease (COPD)? Background: Gabapentinoids are indicated for the...

  • Article

    Gram-Negative Bacteremia: Early Transition from IV to PO Antibiotic Therapy

    March 4, 2025

    Clinical question: What is the safety and efficacy of switching from IV to oral antibiotic therapy after three to five days in patients with gram-negative bacteremia? Background: Bacteremia is...

  • Article

    Finerenone Reduces HF Events in Patients with Preserved Ejection Fraction

    March 4, 2025

    Clinical question: Does finerenone improve outcomes in patients with heart failure (HF) with mildly reduced or preserved ejection fraction? Background: Steroidal mineralocorticoid receptor...

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