Article
Antibiotic Treatment for 7 days is Noninferior to 14 days in Patients with Uncomplicated Bacteremia
June 2, 2025
Clinical question: Is seven days of antibiotic treatment for bloodstream infections noninferior to 14 days of treatment? Background: Bloodstream infections are very common, can originate from a...
Article
Efficacy of Adjuvant Corticosteroid Therapy for CAP Varied Significantly Based on C-Reactive Protein Concentrations
June 2, 2025
Clinical question: Can baseline C-reactive protein concentrations help identify which patients with community-acquired pneumonia (CAP) are most likely to benefit from adjuvant treatment with...
Article
Potential Post-Discharge Benefits of Continuing Metformin During Acute Hospitalization
June 2, 2025
Clinical question: Does the continuation of metformin during hospitalization result in fewer post-hospitalization complications, such as hypoglycemia or death? Background: Despite metformin’s...
Article
Health Systems and Prescribers Can Favor a Single Triple-Therapy Inhaler in COPD that Both Improves Patient Outcomes and Reduces the Climate Impacts of Healthcare
June 2, 2025
Clinical question: How do the two available (U.S. market) single triple-therapy inhalers compare in terms of safety and efficacy for patients with chronic obstructive pulmonary disease (COPD), with...
Article
Sex Disparities in Opioid Prescription Practices on a Hospital Medicine Service
April 1, 2025
Clinical question: Does patient sex influence opioid prescription patterns during hospitalization and at discharge on general medicine services? Background: Clinicians may have sex- and gender-based...
Article
Comparative Effectiveness and Safety of Apixaban, Rivaroxaban, and Warfarin in Patients with Cirrhosis and AF
March 4, 2025
Clinical question: What is the effectiveness and safety of apixaban, rivaroxaban, and warfarin in patients with cirrhosis and atrial fibrillation? Background: The use of direct oral anticoagulants...
Article
Gabapentinoid Use Associated with Increased Risk of Severe Exacerbations in Patientswith COPD
March 4, 2025
Clinical question: Does gabapentinoid use increase the risk of severe exacerbation in patients with chronic obstructive pulmonary disease (COPD)? Background: Gabapentinoids are indicated for the...
Article
Gram-Negative Bacteremia: Early Transition from IV to PO Antibiotic Therapy
March 4, 2025
Clinical question: What is the safety and efficacy of switching from IV to oral antibiotic therapy after three to five days in patients with gram-negative bacteremia? Background: Bacteremia is...
Article
Finerenone Reduces HF Events in Patients with Preserved Ejection Fraction
March 4, 2025
Clinical question: Does finerenone improve outcomes in patients with heart failure (HF) with mildly reduced or preserved ejection fraction? Background: Steroidal mineralocorticoid receptor...
Article
Empagliflozin After Acute Myocardial Infarction
March 4, 2025
Clinical question: Does empagliflozin improve cardiovascular outcomes in patients who have had an acute myocardial infarction? Background: Studies have shown that empagliflozin improves...