Article
Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients
May 1, 2025
Clinical question: Are there alternatives to statins for primary prevention? Background: Statins that lower low-density lipoprotein (LDL) cholesterol are major therapeutics in reducing both primary...
Article
Beta-Blocker Interruption or Continuation after Myocardial Infarction
May 1, 2025
Clinical question: Is the interrupted use of a beta-blocker non-inferior to its continued use in patients with a history of myocardial infarction (MI)? Background: Patients with MI are often started...
Article
Can Salt Stir the Pot? Sodium’s Effect on Heart Failure Clinical Outcomes
April 1, 2025
Clinical question: Is there an association between baseline dietary sodium intake and clinical outcomes in heart failure? Background: Dietary sodium restriction is common advice for patients with...
Article
Comparative Effectiveness and Safety of Apixaban, Rivaroxaban, and Warfarin in Patients with Cirrhosis and AF
March 4, 2025
Clinical question: What is the effectiveness and safety of apixaban, rivaroxaban, and warfarin in patients with cirrhosis and atrial fibrillation? Background: The use of direct oral anticoagulants...
Article
Finerenone Reduces HF Events in Patients with Preserved Ejection Fraction
March 4, 2025
Clinical question: Does finerenone improve outcomes in patients with heart failure (HF) with mildly reduced or preserved ejection fraction? Background: Steroidal mineralocorticoid receptor...
Article
Empagliflozin After Acute Myocardial Infarction
March 4, 2025
Clinical question: Does empagliflozin improve cardiovascular outcomes in patients who have had an acute myocardial infarction? Background: Studies have shown that empagliflozin improves...
Article
Safety of Diltiazem in Patients Taking Apixaban or Rivaroxaban
March 4, 2025
Clinical question: Does diltiazem increase the risk of major bleeding in patients on apixaban or rivaroxaban? Background: Diltiazem is a potent CYP3A4 inhibitor and a mild P-glycoprotein inhibitor....
Article
Coding Corner: Talk the Talk, Bill the Bill: Navigating Advance Care Discussion Billing
January 1, 2025
A 75-year-old woman with a previous medical history of high blood pressure, diabetes mellitus, stage 4 chronic kidney disease, and lung cancer was admitted to the hospital with chest pain and...
Article
Empagliflozin After Acute Myocardial Infarction (EMPACT-MI)
January 1, 2025
Clinical question: Does starting empagliflozin for patients with acute myocardial infarction (AMI) and new onset systolic heart failure (HF) or congestive symptoms reduce the risk of first...
Article
Higher Rates of Major Hemorrhage with Rivaroxaban and Warfarin
December 2, 2024
Clinical question: How effective and safe are apixaban versus rivaroxaban versus warfarin in patients with cirrhosis and nonvalvular atrial fibrillation (AF)? Background: Apixaban, rivaroxaban, and...