Article
The STRONG-HF Trial: Evaluating the Safety, Tolerability, and Effectiveness of Up-titrating GDMT in Acute Heart Failure
August 1, 2024
Clinical question: Does rapid up-titration of guideline-directed medical therapies (GDMT) following admission for acute heart failure improve patient outcomes? Background: GDMT provides...
Article
Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes
August 1, 2024
Clinical question: Is the treatment strategy with ticagrelor superior to prasugrel in acute coronary syndrome (ACS) with planned invasive evaluation at one year? Background: Dual antiplatelet...
Article
Syncope: Things We Do for No Reason & Things We Do for Reason
July 1, 2024
Syncope is broadly classified into reflex-mediated (60% to 70%), orthostatic (10%), and cardiac (10% to 20%). Cerebrovascular causes were removed from American and European guidelines (or listed as a...
Article
Apixaban Reduces Risk of Stroke or Systemic Embolism in Subclinical AF
May 1, 2024
Dr. Watson Clinical question: Does oral anti-coagulation reduce stroke or systemic embolism risk in subclinical atrial fibrillation (AF)? Background: Studies have shown an increased risk of...
Article
High Frequency of AF Recurrence in Hospitalized Patients with New-onset AF
May 1, 2024
Dr. Watson Clinical question: What is the frequency of atrial fibrillation (AF) recurrence in patients with new-onset AF, detected while hospitalized for a noncardiac medical illness or surgery,...
Article
Semaglutide in Patients with HFpEF and Obesity
May 1, 2024
Dr. Cepeda Mora Clinical question: Is semaglutide an effective heart failure treatment in patients with heart failure with preserved ejection fraction (HFpEF) and obesity? Background: HFpEF is...
Article
Frailty Assessment and Perioperative Adverse Cardiovascular Events After Noncardiac Surgery
May 1, 2024
Dr. Chandler Clinical question: Can a frailty assessment tool be used to identify patients at higher risk for major adverse cardiac events (MACE) prior to noncardiac surgery? Background: Studies...
Article
Torsemide or Furosemide After Discharge in Patients Hospitalized with HF
April 1, 2024
Clinical question: Is there a mortality difference in patients discharged on torsemide versus furosemide after heart failure hospitalization? Background: Torsemide has been thought to be superior to...
Article
Risk and Benefit of Secondary Prevention with Aspirin Versus P2Y12 Inhibitor in CAD Patients
April 1, 2024
Clinical question: In patients with coronary artery disease (CAD), what is the difference in risk and benefit between secondary prevention with aspirin (ASA) versus a P2Y12 inhibitor? Background:...
Article
Time to Benefit of SGLT-2 Inhibitors Among Patients with HF
April 1, 2024
Clinical question: What is the time to benefit for patients with heart failure (HF) and prescribed a sodium-glucose cotransporter-2 (SGLT-2) inhibitor? Background: SGLT-2 inhibitors are an effective...