Article
Digitoxin in Patients with HFrEF May Improve Outcomes
June 1, 2026
Clinical question: In patients with chronic heart failure with reduced ejection fraction (HFrEF, defined as left ventricular ejection fraction of up to 40% with New York Heart Association class...
Article
Fluid Restriction Does Not Improve Outcomes in HF Patients
May 1, 2026
Clinical question: Does a restrictive fluid strategy improve clinical outcomes in heart failure (HF) patients compared to liberal fluid intake? Background: Fluid restriction is often recommended for...
Article
Liberal or Restrictive Postoperative Transfusion in Patients at High Cardiac Risk: The TOP Randomized Clinical Trial
May 1, 2026
Clinical question: Does a liberal transfusion strategy decrease the risk of death or major ischemic events after major surgical operations in patients at high risk of cardiac events? Background:...
Article
Anticoagulation and Antiplatelet Therapy in Patients with AF and Atherosclerosis
April 6, 2026
CLINICAL QUESTION: In patients with atherosclerotic disease and concurrent atrial fibrillation, does adding antiplatelet therapy to oral anticoagulation improve net clinical outcomes compared with...
Article
Impact of Long-Term Beta-Blocker Therapy on Death and Recurrent MI in Patients with Acute MI with Preserved Ejection Fraction
April 6, 2026
CLINICAL QUESTION: Does therapy with a beta-blocker reduce mortality and myocardial infarction (MI) in patients with a recent myocardial infarction with preserved ejection fraction? BACKGROUND: The...
Article
Caffeinated Coffee Consumption Reduces AF Recurrence After Electrical Cardioversion
April 6, 2026
CLINICAL QUESTION: What effect does coffee consumption have on atrial fibrillation (AF) after successful electrical cardioversion? BACKGROUND: Coffee is one of the most-consumed beverages, and it...
Article
Comparative Efficacy and Safety of Clopidogrel Versus Aspirin Monotherapy in Patients with Established CAD
April 6, 2026
CLINICAL QUESTION: Does monotherapy with clopidogrel reduce the risk of major adverse cardiovascular or cerebrovascular events (MACCE) compared to monotherapy with aspirin in patients with...
Article
Invasive Versus Conservative Strategy in Older Adults with NSTE-ACS: Fewer Infarctions Without a Mortality Benefit
April 6, 2026
CLINICAL QUESTION: In patients aged 70 years or older with non–ST-segment elevation acute coronary syndrome (NSTEACS), does an invasive strategy reduce mortality and cardiovascular events compared...
Article
Influenza Vaccination Improves All-Cause Mortality and Rates of Readmission for Patients Admitted with Acute HF
March 2, 2026
CLINICAL QUESTION: Does influenza vaccination prior to hospital discharge improve a cause mortality and rates of readmission for patients admitted with acute heart failure (HF)? BACKGROUND:...
Article
Impact of Cardiopulmonary POCUS on Hospital LOS in Patients with Undifferentiated Dyspnea
March 2, 2026
CLINICAL QUESTION: Is cardiopulmonary point-of-care ultrasonography (POCUS) associated with reduced hospital lengths of stay (LOS) in patients with undifferentiated dyspnea? BACKGROUND: POCUS has...