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Latest News

  • Article

    Comparative Effectiveness and Safety of Apixaban, Rivaroxaban, and Warfarin in Patients with Cirrhosis and AF

    March 4, 2025

    Clinical question: What is the effectiveness and safety of apixaban, rivaroxaban, and warfarin in patients with cirrhosis and atrial fibrillation? Background: The use of direct oral anticoagulants...

  • Article

    Gabapentinoid Use Associated with Increased Risk of Severe Exacerbations in Patientswith COPD

    March 4, 2025

    Clinical question: Does gabapentinoid use increase the risk of severe exacerbation in patients with chronic obstructive pulmonary disease (COPD)? Background: Gabapentinoids are indicated for the...

  • Article

    Gram-Negative Bacteremia: Early Transition from IV to PO Antibiotic Therapy

    March 4, 2025

    Clinical question: What is the safety and efficacy of switching from IV to oral antibiotic therapy after three to five days in patients with gram-negative bacteremia? Background: Bacteremia is...

  • Article

    Renal Function and Decongestion with ADHF: the ADVOR Trial

    March 4, 2025

    Clinical question: Does acetazolamide enhance loop diuretic effect in patients with acute decompensated heart failure (ADHF) and how does this combination affect renal function? Background: Nearly...

  • Article

    Finerenone Reduces HF Events in Patients with Preserved Ejection Fraction

    March 4, 2025

    Clinical question: Does finerenone improve outcomes in patients with heart failure (HF) with mildly reduced or preserved ejection fraction? Background: Steroidal mineralocorticoid receptor...

  • Article

    Empagliflozin After Acute Myocardial Infarction

    March 4, 2025

    Clinical question: Does empagliflozin improve cardiovascular outcomes in patients who have had an acute myocardial infarction? Background: Studies have shown that empagliflozin improves...

  • Article

    Slower Correction of Sodium in Severe Hyponatremia is Associated with Increased Mortality and Length of Stay

    March 4, 2025

    Clinical question: Is the sodium correction rate in severe hyponatremia associated with mortality and length of stay? Background: Hyponatremia is commonly encountered in the hospital, with high...

  • Article

    Safety of Diltiazem in Patients Taking Apixaban or Rivaroxaban

    March 4, 2025

    Clinical question: Does diltiazem increase the risk of major bleeding in patients on apixaban or rivaroxaban? Background: Diltiazem is a potent CYP3A4 inhibitor and a mild P-glycoprotein inhibitor....

  • Article

    Semaglutide Decreases Risk of Kidney Failure, Worsening of Kidney Disease, and Kidney-Related or Cardiovascular Death

    March 4, 2025

    Clinical question: Does treatment with semaglutide in patients with chronic kidney disease (CKD) and diabetes mellitus (DM) type II reduce the risk of kidney failure, progression of chronic kidney...

  • Article

    Absence of CSF Pleocytosis Prevalent in Encephalitis and Can Delay Empiric Treatment

    March 4, 2025

    Clinical question: Is there a difference in clinical factors and outcomes among patients with new-onset encephalitis based on whether their initial cerebrospinal fluid (CSF) studies demonstrate the...

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