News
NSAID Use by Patients on Antithrombotic Therapy Has Bleeding, Cardiovascular Risks
June 8, 2015
Clinical question: Is there increased risk of bleeding or cardiovascular events when using NSAIDs while on antithrombotic therapy for secondary cardiovascular prevention? Background: NSAIDs are among the most commonly used medications, despite the fact that individual NSAIDs have been associated
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Treatment of Patients with Atrial Fibrillation, Low CHA2DS2-VASc Scores
June 8, 2015
Clinical question: Is anticoagulation beneficial for patients with atrial fibrillation (Afib) and low CHA2DS2-VASc score (0 for men, 1 for women) or for those with one additional stroke risk factor? Background: Guidelines nearly universally recommend anticoagulation for patients with a CHA2DS2-VA
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Research Review: Ticagrelor for Post-Myocardial Infarction
June 8, 2015
Clinical question: Is ticagrelor for secondary prevention indicated for more than one year after myocardial infarction (MI)? Background: The efficacy and safety of ticagrelor combined with low-dose aspirin more than one year after MI for secondary prevention has not previously been established.
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D-Dimer Not Reliable Marker to Stop Anticoagulation Therapy
May 5, 2015
Clinical question: In patients with a first unprovoked VTE, is it safe to use a normalized D-dimer test to stop anticoagulation therapy? Background: The risk of VTE recurrence after stopping anticoagulation is higher in patients who have elevated D-dimer levels after treatment.
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Noninvasive Ventilation Improves Outcomes for COPD Inpatients
May 5, 2015
Clinical question: Do patients hospitalized with acute COPD exacerbations have improved outcomes with noninvasive ventilation (NIV) compared to those treated with invasive mechanical ventilation (IMV)? Background: Previous studies have shown that in select patients, NIV has a mortality benefit ov
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Bova Risk Model Predicts 30-Day Pulmonary Embolism-Related Complications
May 5, 2015
Clinical question: Can the Bova risk model stratify patients with acute PE into stages of increasing risk for 30-day pulmonary embolism (PE)-related complications? Background: The Bova score is based on four variables assessed at the time of PE diagnosis: heart rate, systolic blood pressure, card
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Intracranial Bleeding Risk for Head Injury Patients on Warfarin
May 5, 2015
High bleeding rates reported for patients taking warfarin after minor, minimal head injuries
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Enriched Nutritional Formulas Help Heal Pressure Ulcers
May 5, 2015
Arginine, zinc, antioxidant-supplemented formulas improve healing in malnourished patients
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High-Volume Hospitals Have Higher Readmission Rates
May 5, 2015
Clinical question: Is there an association between hospital volume and hospital readmission rates? Background: There is an established association between high patient volume and reduced complications or mortality after surgical procedures; however, readmission represents a different type of qual
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Hospital Testing Overuse Done to Reassure Patients, Families
May 5, 2015
Clinical Question: What is the extent of, and factors associated with, testing overuse in U.S.