Article
Most patients meeting sepsis criteria in the emergency department do not have a sepsis diagnosis
February 3, 2022
Dr. Taghvaei Clinical question: What percentage of patients treated for sepsis in the ED are diagnosed with sepsis at discharge? Background: Sepsis is a leading cause of death around the world...
Article
Treatment of acute pain in adults with sickle cell disease in an infusion center versus the emergency department resulted in faster treatment and fewer hospitalizations
February 3, 2022
Clinical question: Are outcomes better for sickle cell patients experiencing vaso-occlusive crises (VOCs) when treated in an infusion center (IC) rather than an emergency department...
Article
Active diagnostic strategy for pulmonary embolism in COPD exacerbations does not significantly alter a composite clinical outcome compared to usual care
January 7, 2022
Dr. Lublin Clinical question: Can an active diagnostic protocol including a D-dimer and computed tomography pulmonary angiogram (CTPA) for pulmonary emboli (PE) improve outcomes for...
Article
Effect of vasopressin and methylprednisolone versus placebo on return of spontaneous circulation in patients with in-hospital cardiac arrest
January 7, 2022
Dr. Miller Clinical question: Does the administration of vasopressin and methylprednisolone during in-hospital cardiac arrest improve the likelihood of return of spontaneous circulation...
Article
Maintenance or discontinuation of antidepressants
January 7, 2022
Dr. Miller Clinical question: For patients on longstanding antidepressant therapy who feel well enough to discontinue antidepressants, what is the risk of relapse with maintaining or...
Article
Effective therapy for heart failure with preserved ejection fraction
January 7, 2022
Dr. Anderson Clinical question: What effect do sodium-glucose cotransporter 2 (SGLT2) inhibitors have on outcomes in adults with heart failure with preserved ejection fraction...
Article
Empiric therapeutic anticoagulation for severe COVID-19
January 7, 2022
Dr. Anderson Clinical question: For patients hospitalized with COVID-19, does empiric therapeutic-dose versus prophylactic-dose anticoagulation with enoxaparin affect clinical...
Article
Many hospitalized patients with type 2 diabetes and mild hyperglycemia on admission can be managed with sliding scale insulin alone
January 7, 2022
Dr. Knees Clinical question: In patients with mild hyperglycemia on admission, can sliding scale insulin (SSI) alone be used for blood glucose (BG) control? Background: Prior randomized...
Article
Administration of probiotic did not reduce ventilator-associated pneumonia in critically ill patients requiring mechanical ventilation
January 7, 2022
Dr. Berry Clinical question: Does administration of probiotic L rhamnosus GG to critically ill patients requiring mechanical ventilation decrease ventilator-associated pneumonia (VAP)...
Article
No benefit for immediate intervention for infected necrotizing pancreatitis
January 7, 2022
Dr. Berry Clinical question: Is drainage within 24 hours of diagnosis of infected necrotizing pancreatitis superior at preventing complications? Background: Diagnosis of infected necrotizing...