Article
Direct oral anticoagulants may be safe in cancer-related venous thromboembolisms, but use caution with gastrointestinal malignancies
February 3, 2022
Clinical question: Are direct oral anticoagulants (DOACs) a suitable alternative to low molecular weight heparin (LMWH) for treatment of venous thromboembolism (VTE) in patients with underlying...
Article
Breakthrough infection in COVID-19-vaccinated health care workers is associated with lower levels of neutralizing antibodies but less severe disease
February 3, 2022
Clinical question: How frequent are breakthrough infections in health care workers fully vaccinated against COVID-19, and how does vaccination correlate with immune response and infectivity? ...
Article
Aspirin increases the risk of clinically significant gastrointestinal bleeding in older persons
February 3, 2022
Clinical question: Does aspirin impact the risk of clinically significant gastrointestinal (GI) bleeding compared with placebo in community-dwelling older persons (aged >/= 70 years)? Dr....
Article
Advocating for a patient-based approach to decisions of gastrostomy-tube placement in patients with dementia
February 3, 2022
Clinical question: Should providers universally not recommend feeding tubes in patients with dementia and poor oral intake? Dr. Day Background: The natural progression of advancing dementia...
Article
Hypertonic saline solution with furosemide infusion may be beneficial in fluid overload in patients with reduced ejection fraction
February 3, 2022
Clinical question: Is simultaneous infusion of hypertonic saline and IV furosemide more efficacious than IV furosemide alone in patients with fluid overload? Dr. Obisesan Background:...
Article
Most patients meeting sepsis criteria in the emergency department do not have a sepsis diagnosis
February 3, 2022
Dr. Taghvaei Clinical question: What percentage of patients treated for sepsis in the ED are diagnosed with sepsis at discharge? Background: Sepsis is a leading cause of death around the world...
Article
Treatment of acute pain in adults with sickle cell disease in an infusion center versus the emergency department resulted in faster treatment and fewer hospitalizations
February 3, 2022
Clinical question: Are outcomes better for sickle cell patients experiencing vaso-occlusive crises (VOCs) when treated in an infusion center (IC) rather than an emergency department...
Article
Active diagnostic strategy for pulmonary embolism in COPD exacerbations does not significantly alter a composite clinical outcome compared to usual care
January 7, 2022
Dr. Lublin Clinical question: Can an active diagnostic protocol including a D-dimer and computed tomography pulmonary angiogram (CTPA) for pulmonary emboli (PE) improve outcomes for...
Article
Effect of vasopressin and methylprednisolone versus placebo on return of spontaneous circulation in patients with in-hospital cardiac arrest
January 7, 2022
Dr. Miller Clinical question: Does the administration of vasopressin and methylprednisolone during in-hospital cardiac arrest improve the likelihood of return of spontaneous circulation...
Article
Maintenance or discontinuation of antidepressants
January 7, 2022
Dr. Miller Clinical question: For patients on longstanding antidepressant therapy who feel well enough to discontinue antidepressants, what is the risk of relapse with maintaining or...