Article
Mirtazapine is Not an Effective Treatment for Agitation in Dementia
September 1, 2022
Ms. Whalen CLINICAL QUESTION: What’s the clinical effectiveness and safety profile of mirtazapine in reducing agitation in dementia relative to placebo? BACKGROUND: Nonpharmacological...
Article
Oral Antibiotics and a Combination Regimen of IV and Oral Antibiotics for Treatment of Acute Uncomplicated Appendicitis Yielded Similar Success Rates
September 1, 2022
Dr. Andleeb Clinical question: Are oral antibiotics effective and non-inferior to a combination of intravenous and oral antibiotics? Background: Evidence over the past 10 years suggests that...
Article
Low-dose Rivaroxaban at Discharge Prevented Some VTE Events at One Month for High-risk Patients Recovering from COVID-19
September 1, 2022
Dr. Thazhatuveetil-Kunhahamed Clinical Question: Is extended rivaroxaban prophylaxis (10 mg daily for 35 days) protective against arterial and venous thromboembolism (VTE) events in COVID-19...
Article
The risk for intestinal necrosis with SPS is very low
August 1, 2022
Dr. Lippert Clinical question: What is the risk of intestinal necrosis with sodium polystyrene (SPS) for the treatment of hyperkalemia? Background: SPS is a medication that has been available...
Article
Initiation of pulmonary rehabilitation after admission for COPD exacerbation decreases rehospitalizations
August 1, 2022
Ms. Langford Clinical question: Does the initiation of pulmonary rehabilitation after hospitalization for a chronic obstructive pulmonary disease (COPD) exacerbation impact...
Article
Tranexamic acid minimized perioperative bleeding in patients undergoing noncardiac surgery
August 1, 2022
Dr. Menon Clinical question: Does tranexamic acid reduce the incidence of life-threatening perioperative bleeding in patients undergoing noncardiac surgery without increasing the risk of major...
Article
IV fluid resuscitation at a slow rate in ICU patients did not reduce 90-day mortality
August 1, 2022
Mr. Haller Clinical question: Is there a difference in the 90-day mortality for patients admitted to the ICU receiving a fast (999 mL/hour) versus slow (333 mL/hour) IV infusion...
Article
DES reduce the risk of ISR in patients with ICAS compared to BMS
August 1, 2022
Dr. Snipe Clinical question: In patients with symptomatic high-grade intracranial atherosclerotic stenosis (ICAS), does the use of a drug-eluting stent (DES) reduce the incidence of in-stent...
Article
Adding a new antihypertensive medication is associated with improved blood pressure lowering
August 1, 2022
Dr. Chevli Clinical question: Which is the better strategy for treatment intensification in older patients with hypertension—maximizing the antihypertensive or adding a new...
Article
Steroid Dosing, Surgery Outcomes for COVID-19 Patients, and More: Highlights from 2021 Research
July 1, 2022
Drs. Frank and Grant did an outstanding job with their in-person In the Literature at SHM Converge. Whether to use a standard or a personalized dose of corticosteroids in hospitalized patients...