Article
Associations of Apixaban Dose with Safety and Effectiveness Outcomes in Patients with Atrial Fibrillation and Severe CKD
April 1, 2024
Clinical question: Is the use of standard-dose apixaban based on creatinine criteria placing patients at higher risk of bleeding? Background: The U.S. Food and Drug Administration recommends...
Article
Time to Rethink AF Treatment: Prolonged Benefits of Cryoballoon Ablation
March 1, 2024
Clinical question: Does initial therapy with catheter cryoballoon ablation reduce progression to persistent atrial fibrillation (AF) in patients with symptomatic, paroxysmal AF when compared to...
Article
Longer-term Outcomes in Critically Ill Patients with COVID-19 in the REMAP-CAP Trial
March 1, 2024
Clinical question: What is the longer-term (180-day) mortality effect of common therapies on critically ill patients with COVID-19? Background: Most randomized clinical trials for patients with...
Article
Main Causes of Costly Inappropriate Hospital Admissions are Premature Admission and the Potential for Outpatient Management
March 1, 2024
Clinical question: How prevalent and costly are inappropriate hospital admissions and are patients’ intrinsic risk factors (IRFs) or comorbidities associated with inappropriate hospital...
Article
Use of Amiodarone with Apixaban or Rivaroxaban Increases Risk for Bleeding-related Hospitalizations
March 1, 2024
Clinical question: Does the use of amiodarone in patients with atrial fibrillation increase the risk for bleeding-related hospitalizations when used with apixaban or rivaroxaban? Background:...
Article
Initial Aggressive Diuresis in Patients Hospitalized with Acute HF
March 1, 2024
Clinical question: For patients admitted with acute heart failure, is early and aggressive diuresis associated with improved dyspnea without an associated worsening in renal function? Background:...
Article
Periprocedural Management of Patients with AF Receiving a DOAC Undergoing a Digestive Endoscopy
March 1, 2024
Clinical question: How long should patients with atrial fibrillation (AF) on a direct oral anticoagulant (DOAC) hold anticoagulation when undergoing endoscopy? Background: Given limited direct...
Article
DOACs Versus LMWH and Recurrent VTE in Patients with Cancer
March 1, 2024
Clinical question: Are direct oral anticoagulants (DOACs) acceptable compared to low-molecular-weight heparin (LMWH) for preventing venous thromboembolism (VTE) with a safe bleeding risk in cancer...
Article
Opioids Confer Risk without Improved Pain Control
March 1, 2024
Clinical question: How effective and safe are opioids for the treatment of acute, non-specific low back and neck pain? Background: Despite the lack of evidence of the effectiveness of opioids for...
Article
Reducing Use of NPO After Midnight for Inpatient Diagnostic and Therapeutic Procedures
March 1, 2024
Clinical question: Can an interprofessional quality improvement team reduce the use of nil per os (NPO) after midnight orders prior to inpatient diagnostic and therapeutic procedures requiring...