Article
Time to Benefit of SGLT-2 Inhibitors Among Patients with HF
April 1, 2024
Clinical question: What is the time to benefit for patients with heart failure (HF) and prescribed a sodium-glucose cotransporter-2 (SGLT-2) inhibitor? Background: SGLT-2 inhibitors are an effective...
Article
Reliability of Admission Procalcitonin Testing for Capturing Bacteremia Across the Sepsis Spectrum
April 1, 2024
Clinical question: Can serum procalcitonin reliably detect bloodstream infections upon hospital admission? Background: Hospitalists frequently manage patients with bacteremia, which is often...
Article
Pitavastatin to Prevent Cardiovascular Disease in HIV Infection
April 1, 2024
Clinical question: Does pitavastatin decrease major adverse cardiovascular events (MACEs) in patients infected by the human immunodeficiency virus (HIV) who are on antiretroviral therapy (ART) and...
Article
DAPT Versus Alteplase for Patients With Minor Non-disabling Acute Ischemic Stroke
April 1, 2024
Clinical question: Is dual antiplatelet therapy (DAPT) non-inferior to intravenous thrombolysis in patients with minor non-disabling acute ischemic stroke? Background: Intravenous thrombolytics are...
Article
Early Restrictive or Liberal Fluid Management for Sepsis-induced Hypotension
April 1, 2024
Clinical question: What’s the effect of restrictive versus liberal fluid resuscitation strategies in sepsis-induced hypotension on 90-day mortality? Background: Intravenous fluid resuscitation is...
Article
Moderate-intensity Statin With Ezetimibe Combination Therapy Versus High-intensity Statin Monotherapy in Patients at Very High Risk of ASCVD
April 1, 2024
Clinical question: Can you use a moderate-intensity statin with ezetimibe combination therapy for very high-risk (VHR) patients with ASCVD? Background: The ACC/AHA guidelines recommend the use of...
Article
Aspirin or LMWH for Thromboprophylaxis After a Fracture
April 1, 2024
Clinical question: Can you use aspirin as a safe alternative to low-molecular-weight heparin (LMWH) for thromboprophylaxis in patients with an extremity fracture? Background: Many guidelines...
Article
Comparison of Standard Dose, High Dose, and Therapeutic Anticoagulation in Hypoxemic COVID-19 Patients
April 1, 2024
Clinical question: Does standard-dose prophylactic anticoagulation (SD-PA), high-dose prophylactic anticoagulation (HD-PA), or therapeutic anticoagulation (TA) have a greater benefit in patients with...
Article
Hydrocortisone in Severe CAP
April 1, 2024
Clinical question: Do the anti-inflammatory and immunomodulatory effects of glucocorticoids decrease mortality among patients with severe community-acquired pneumonia (CAP)? Background: CAP remains...
Article
DOACs Versus Warfarin Across the Spectrum of Kidney Function
April 1, 2024
Clinical question: How safe are direct oral anticoagulants (DOACs) to use in kidney dysfunction? Background: DOACs are increasingly being used in patients with kidney dysfunction. DOACs are cleared,...