Article
Operative Versus Non-Operative Treatment of Acute Cholecystitis in Older Adults with Multiple Comorbidities–Advocating for Definitive Care
July 31, 2025
Clinical question: In patients 65 years and older, with multimorbidity, and presenting with acute cholecystitis, is operative treatment more efficacious than non-operative treatment? Background:...
Article
Prescribed In-Hospital Sodium Intake for ADHF: A Systematic Review and Meta-Analysis
July 31, 2025
Clinical question: Does prescribed oral and/or IV sodium supplementation plus loop diuretic administration improve outcomes for patients hospitalized with acute decompensated heart failure...
Article
Carvedilol Versus Propranolol for the Prevention of Decompensation and Mortality in Patients with Compensated and Decompensated Cirrhosis
July 31, 2025
Clinical question: Is carvedilol more effective than the classical non-selective beta-blockers (cNSBBs) propranolol or nadolol in preventing first decompensation and in reducing mortality in patients...
Article
Hospital Addiction Consultative Service Increases MOUD Initiation and Linkage to Follow-up After Discharge
July 31, 2025
Clinical question: Does an addiction-focused consult service increase medications for opioid use disorder (MOUD) initiation during inpatient hospitalization and connect patients to follow-up care...
Article
Oral Versus Extended-Release Injectable Naltrexone for Hospitalized Patients With AUD
July 31, 2025
Clinical question: Is there a difference in effectiveness between oral and injectable naltrexone at discharge for alcohol use disorder (AUD)? Background: AUD is common among inpatients, and most do...
Article
IV Ferric Carboxymaltose in Heart Failure with Iron Deficiency
July 31, 2025
Clinical question: Does IV ferric carboxymaltose improve clinical outcomes in patients with heart failure (HF) and iron deficiency? Background: Iron deficiency affects up to half of patients with HF...
Article
Feeding Tube Use Still Common in Hospitalized Older Adults with Dementia
July 31, 2025
Clinical question: How frequently are feeding tubes placed during hospitalization in older adults with dementia, and what patient or regional factors influence their use? Background: Feeding tube...
Article
Time to Rethink SBP. Do the Harms Outweigh the Benefits?
July 31, 2025
Clinical question: In the context of increasing antibiotic resistance and changing microbiology of Spontaneous Bacterial Peritonitis (SBP), does secondary SBP prophylaxis reduce the recurrence of SBP...
Article
IV Tenecteplase Before Thrombectomy in Stroke
July 31, 2025
Clinical question: Does IV Tenecteplase administered before endovascular thrombectomy lead to a higher likelihood of functional independence at 90 days compared to endovascular thrombectomy...
Article
Structured Exercise After Adjuvant Chemotherapy for Colon Cancer
July 31, 2025
Clinical question: Does a three-year structured exercise program, started after adjuvant chemotherapy, improve disease-free and overall survival in patients with resected colon cancer compared to...