Article
Antibiotic Treatment for 7 days is Noninferior to 14 days in Patients with Uncomplicated Bacteremia
June 2, 2025
Clinical question: Is seven days of antibiotic treatment for bloodstream infections noninferior to 14 days of treatment? Background: Bloodstream infections are very common, can originate from a...
Article
Restrictive Transfusion in MI May Lead to an Increase in 6-Month Mortality
June 2, 2025
Clinical question: How does a restrictive transfusion strategy (transfusion threshold of 7 to 8 g/dL) compare to a liberal transfusion strategy (transfusion threshold of 10 g/dL) in patients with...
Article
Efficacy of Adjuvant Corticosteroid Therapy for CAP Varied Significantly Based on C-Reactive Protein Concentrations
June 2, 2025
Clinical question: Can baseline C-reactive protein concentrations help identify which patients with community-acquired pneumonia (CAP) are most likely to benefit from adjuvant treatment with...
Article
Potential Post-Discharge Benefits of Continuing Metformin During Acute Hospitalization
June 2, 2025
Clinical question: Does the continuation of metformin during hospitalization result in fewer post-hospitalization complications, such as hypoglycemia or death? Background: Despite metformin’s...
Article
Should Hospitalists Throw Caution to the Wind? Overly Cautious Correction of Severe Hyponatremia May Lead to Greater Harm Than Good
June 2, 2025
Clinical question: Does the correction rate for hospitalized adults with severe hyponatremia correlate with mortality or length of stay? Background: Hyponatremia is a commonly encountered problem...
Article
Evidence for Reduced-Dose DOAC in Those at High Risk for VTE Recurrence in Extended Phase Anticoagulation: The RENOVE Trial
June 2, 2025
Clinical question: Is extended-phase anticoagulation with dose-reduced direct oral anticoagulants (DOACs) as effective and safe as full-dose DOACs in those with venous thromboembolism (VTE) at high...
Article
Addiction Consultation and Medications for Substance Use Disorders Associated with Reduced 30-Day Readmission Rates
June 2, 2025
Clinical question: In patients with opioid use disorder (OUD) and alcohol use disorder (AUD), do addiction consultations or medications for opioid use disorder (MOUD) and alcohol use disorder (MAUD)...
Article
Health Systems and Prescribers Can Favor a Single Triple-Therapy Inhaler in COPD that Both Improves Patient Outcomes and Reduces the Climate Impacts of Healthcare
June 2, 2025
Clinical question: How do the two available (U.S. market) single triple-therapy inhalers compare in terms of safety and efficacy for patients with chronic obstructive pulmonary disease (COPD), with...
Article
Naturalized Citizens and Noncitizen Immigrant Healthcare Workers are Important Members of the Workforce
June 2, 2025
Clinical question: How do the Trump administration’s plans for deporting undocumented immigrants and some individuals with temporary protected status impact the already strained healthcare...
Article
Perioperative Strategy for RASI
May 1, 2025
Clinical question: Should renin-angiotensin system inhibitors (RASI) be continued or discontinued before major noncardiac surgery? Background: Continuation of RASI perioperatively can predispose to...