Article
Weekly Tirzepatide Increases the Rate of Resolution for MASH
November 3, 2025
CLINICAL QUESTION: Does tirzepatide improve the rate of resolution of Metabolic Dysfunction-Associated Steatohepatitis (MASH) or decrease the fibrosis stage in patients with steatohepatitis and...
Article
New Picture Stimuli for the NIHSS Validated
November 3, 2025
CLINICAL QUESTION: Does an updated National Institutes of Health Stroke Scale (NIHSS) language assessment tool perform well in a sample of diverse, neurologically unimpaired English-speaking...
Article
Comparing Efficacy and Safety Between Patients with AF Taking DOACs or Warfarin After a DOAC Failure
November 3, 2025
CLINICAL QUESTION: Is warfarin better as a second-line anticoagulant than another direct oral anticoagulant (DOAC) in patients with atrial-fibrillation-induced ischemic strokes after failure of a...
Article
Beta-Blockers Didn’t Reduce Mortality After Acute MI in Patients with Preserved Ejection Fraction
November 3, 2025
CLINICAL QUESTION: Do beta-blockers still reduce mortality after acute myocardial infarction (MI) in the modern era of faster and better reperfusion strategies? BACKGROUND: Beta-blockers have...
Article
iStopMM Risk Score Helps Predict Which MGUS Patients Need Bone Marrow Biopsy
November 3, 2025
CLINICAL QUESTION: Does my patient with a monoclonal protein and probable monoclonal gammopathy of undetermined significance (MGUS) need a bone marrow biopsy to rule out smoldering multiple myeloma...
Article
Anticoagulation Safety in Patients with Cirrhosis and AF
November 3, 2025
CLINICAL QUESTION: Do patients with cirrhosis and AF who are treated with anticoagulation have increased adverse safety events compared with patients with cirrhosis and AF who are not treated with...
Article
Timely Cessation of PPIs in Critically Ill Patients is Associated with Mortality and Morbidity Reduction
November 3, 2025
CLINICAL QUESTION: Does the timely cessation of proton pump inhibitors (PPIs) in critically ill patients impact morbidity and mortality compared to those who continue PPI therapy? BACKGROUND: PPIs...
Article
Apixaban Versus Aspirin for Subclinical AF: Stroke Prevention and Bleeding Risk
November 3, 2025
CLINICAL QUESTION: Does apixaban reduce the risk of stroke or systemic embolism compared to aspirin in patients with subclinical atrial fibrillation and elevated stroke risk? BACKGROUND: Subclinical...
Article
Octreotide LAR Reduced Transfusion Needs and Endoscopic Interventions in Angiodysplasia-Related Anemia
November 3, 2025
CLINICAL QUESTION: Does octreotide long-acting release (LAR) reduce transfusion requirements in patients with angiodysplasia-related anemia? BACKGROUND: Angiodysplasias frequently cause refractory...
Article
Using AI/NLP to Improve Clinical Efficiency and Drive Patient-Centered Care in Cancer Research
October 1, 2025
CLINICAL QUESTION: Should clinicians use artificial intelligence with natural language processing (AI/NLP) to assess patient messages and review patient concerns to further develop meaningful, novel...