Article
Anticoagulation and Antiplatelet Therapy in Patients with AF and Atherosclerosis
April 6, 2026
CLINICAL QUESTION: In patients with atherosclerotic disease and concurrent atrial fibrillation, does adding antiplatelet therapy to oral anticoagulation improve net clinical outcomes compared with...
Article
Impact of Long-Term Beta-Blocker Therapy on Death and Recurrent MI in Patients with Acute MI with Preserved Ejection Fraction
April 6, 2026
CLINICAL QUESTION: Does therapy with a beta-blocker reduce mortality and myocardial infarction (MI) in patients with a recent myocardial infarction with preserved ejection fraction? BACKGROUND: The...
Article
Caffeinated Coffee Consumption Reduces AF Recurrence After Electrical Cardioversion
April 6, 2026
CLINICAL QUESTION: What effect does coffee consumption have on atrial fibrillation (AF) after successful electrical cardioversion? BACKGROUND: Coffee is one of the most-consumed beverages, and it...
Article
Bedside Chair Placement Increases Physician Sitting and Patient Satisfaction Without Extending Visit Duration
April 6, 2026
CLINICAL QUESTION: Does the simple “nudge” of placing a chair near a patient’s bedside influence how often hospitalist physicians sit during consultations and improve patient...
Article
Comparative Efficacy and Safety of Clopidogrel Versus Aspirin Monotherapy in Patients with Established CAD
April 6, 2026
CLINICAL QUESTION: Does monotherapy with clopidogrel reduce the risk of major adverse cardiovascular or cerebrovascular events (MACCE) compared to monotherapy with aspirin in patients with...
Article
Optimal Timing of Anticoagulation Initiation After Ischemic Stroke in Patients with AF
April 6, 2026
CLINICAL QUESTION: In patients with atrial fibrillation (AF) and acute ischemic stroke, does early anticoagulation initiation (within four days) improve outcomes compared to delayed...
Article
Optimal Management of Febrile Neutropenia in Oncologic and Oncohematologic Patients
April 6, 2026
CLINICAL QUESTION: Is initial empiric antibiotic coverage important in patients with febrile neutropenia? How should the therapeutic strategy be defined? BACKGROUND: Febrile neutropenia is defined...
Article
Low-Dose Glucocorticoids Reduce Mortality in CAP
April 6, 2026
CLINICAL QUESTION: Do glucocorticoids reduce mortality in hospitalized adults with community-acquired pneumonia in a resource-limited setting? BACKGROUND: The use of glucocorticoids as adjunctive...
Article
Invasive Versus Conservative Strategy in Older Adults with NSTE-ACS: Fewer Infarctions Without a Mortality Benefit
April 6, 2026
CLINICAL QUESTION: In patients aged 70 years or older with non–ST-segment elevation acute coronary syndrome (NSTEACS), does an invasive strategy reduce mortality and cardiovascular events compared...
Article
The Apparent Increase in the Incidence of Early-Onset Cancer in the U.S. Population
April 6, 2026
CLINICAL QUESTION: Does the observed rise in cancer rates reflect a true increase in incidence, or is it primarily attributable to heightened diagnostic scrutiny? BACKGROUND: In recent years, the...