Article
Perioperative Strategy for RASI
May 1, 2025
Clinical question: Should renin-angiotensin system inhibitors (RASI) be continued or discontinued before major noncardiac surgery? Background: Continuation of RASI perioperatively can predispose to...
Article
Continuous Versus Intermittent Infusion of β-Lactam Antibiotics in Critically Ill Patients with Sepsis
May 1, 2025
Clinical question: Does continuous infusion of β-lactam antibiotics reduce 90-day mortality compared with intermittent infusion in critically ill patients with sepsis? Background: Sepsis, a...
Article
Healthcare Worker Well-Being After a 5-hour Continuous Communication and Intervention: The Well-B Randomized Clinical Trial
May 1, 2025
Clinical question: Does a brief continuing education intervention improve the well-being of healthcare workers (HCWs)? Background: HCWs’ well-being has been severely impacted, particularly after...
Article
MOUD and Behavioral Health Interventions after Nonfatal Drug Overdose
May 1, 2025
Clinical question: How often are medications for opioid use disorder (MOUD), naloxone, and behavioral health services prescribed after a nonfatal drug overdose, and what is the association between...
Article
Lactated Ringer’s Administration Improved Outcomes Over Normal Saline Administration During Sickle Cell Vaso-Occlusive Episode
May 1, 2025
Clinical question: Is there a difference in the effectiveness of sickle cell vaso-occlusive episode treatment with lactated Ringer’s (LR) solution versus normal saline (NS)? Background: Initial...
Article
Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients
May 1, 2025
Clinical question: Are there alternatives to statins for primary prevention? Background: Statins that lower low-density lipoprotein (LDL) cholesterol are major therapeutics in reducing both primary...
Article
Beta-Blocker Interruption or Continuation after Myocardial Infarction
May 1, 2025
Clinical question: Is the interrupted use of a beta-blocker non-inferior to its continued use in patients with a history of myocardial infarction (MI)? Background: Patients with MI are often started...
Stewardship Prompts to Improve Antibiotic Selection for UTI
May 1, 2025
Clinical question: Can computerized provider order entry (CPOE) prompts reduce the use of empiric extended-spectrum antibiotics in patients with urinary tract infections (UTI)? Background: UTIs...
Article
Effects of Semaglutide on CKD in Patients with Type 2 Diabetes: the FLOW Trial
April 1, 2025
Clinical question: Does treatment with semaglutide in patients with type 2 diabetes and chronic kidney disease (CKD) prevent the progression of CKD or death from kidney and cardiovascular...
Article
High-Flow Nasal Cannula Versus Non-Invasive Ventilation for AECOPD
April 1, 2025
Clinical question: Is high-flow nasal cannula oxygen therapy (HFNC) non-inferior to non-invasive ventilation (NIV) for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in...