Article
Circadian Rhythms in Night Shift Medical Staff
December 1, 2025
CLINICAL QUESTION: Night shift work exposes medical personnel to a range of physiological and psycho-cognitive health risks. Are there evidence-based strategies that can help mitigate these...
Article
Catheter Ablation Versus Antiarrhythmic Drug Therapy for Ventricular Tachycardia
December 1, 2025
CLINICAL QUESTION: Among patients with ischemic cardiomyopathy and ventricular tachycardia, is catheter ablation or antiarrhythmic drug therapy a more effective initial strategy BACKGROUND:...
Article
Optimal Dose of Intranasal Insulin Administration for Reducing Postoperative Delirium Incidence in Older Patients Undergoing Hip Fracture Surgery
December 1, 2025
CLINICAL QUESTION: Does intranasal insulin administration reduce postoperative delirium in older patients undergoing hip fracture surgery? BACKGROUND: Cerebral hypometabolism may be a therapeutic...
Article
Role of Ponsegromab in Treating Malignancy-Related Cachexia
December 1, 2025
CLINICAL QUESTION: Does treatment with ponsegromab, a monoclonal antibody inhibiting growth differentiation factor 15 (GDF-15), improve weight gain in patients with malignancy? BACKGROUND: Patients...
Article
Characteristics of Inpatient Code Status Discussions
December 1, 2025
CLINICAL QUESTION: What are the characteristics of inpatient code status discussions, and how can they be improved? BACKGROUND: Code status discussions are highly prevalent and encouraged in the...
Article
Monoclonal Antibody Abelacimab Compared to Rivaroxaban Had Lower Rates of Bleeding Complications
December 1, 2025
CLINICAL QUESTION: Can the inhibition of free factor XI with a monoclonal antibody be used for stroke prevention in Atrial fibrillation patients? BACKGROUND: Atrial fibrillation is a common...
Article
Inebilizumab Can Treat IgG4-Related Disease
December 1, 2025
CLINICAL QUESTION: Is inebilizumab a safe and effective treatment option for IgG4-related disease? BACKGROUND: Treatment for IgG4-related disease flares currently involves glucocorticoid use and...
Article
Extended Reduced-Dose Apixaban for Treatment of VTE in Cancer Patients
December 1, 2025
CLINICAL QUESTION: Following full-dose treatment for six months, is reduced-dose apixaban noninferior to full-dose apixaban for the prevention of further recurrence of venous thromboembolism (VTE) in...
Article
Statin Use and Risk of HCC, Hepatic Decompensation, and Liver Fibrosis in Patients with Chronic Liver Disease
December 1, 2025
CLINICAL QUESTION: Does statin use lower the risk of hepatocellular carcinoma (HCC) and hepatic decompensation in patients with chronic liver disease by mitigating liver fibrosis...
Article
Weekly Tirzepatide Increases the Rate of Resolution for MASH
November 3, 2025
CLINICAL QUESTION: Does tirzepatide improve the rate of resolution of Metabolic Dysfunction-Associated Steatohepatitis (MASH) or decrease the fibrosis stage in patients with steatohepatitis and...