Article
Maintenance or discontinuation of antidepressants
January 7, 2022
Dr. Miller Clinical question: For patients on longstanding antidepressant therapy who feel well enough to discontinue antidepressants, what is the risk of relapse with maintaining or...
Article
Effective therapy for heart failure with preserved ejection fraction
January 7, 2022
Dr. Anderson Clinical question: What effect do sodium-glucose cotransporter 2 (SGLT2) inhibitors have on outcomes in adults with heart failure with preserved ejection fraction...
Article
Empiric therapeutic anticoagulation for severe COVID-19
January 7, 2022
Dr. Anderson Clinical question: For patients hospitalized with COVID-19, does empiric therapeutic-dose versus prophylactic-dose anticoagulation with enoxaparin affect clinical...
Article
Many hospitalized patients with type 2 diabetes and mild hyperglycemia on admission can be managed with sliding scale insulin alone
January 7, 2022
Dr. Knees Clinical question: In patients with mild hyperglycemia on admission, can sliding scale insulin (SSI) alone be used for blood glucose (BG) control? Background: Prior randomized...
Article
Administration of probiotic did not reduce ventilator-associated pneumonia in critically ill patients requiring mechanical ventilation
January 7, 2022
Dr. Berry Clinical question: Does administration of probiotic L rhamnosus GG to critically ill patients requiring mechanical ventilation decrease ventilator-associated pneumonia (VAP)...
Article
No benefit for immediate intervention for infected necrotizing pancreatitis
January 7, 2022
Dr. Berry Clinical question: Is drainage within 24 hours of diagnosis of infected necrotizing pancreatitis superior at preventing complications? Background: Diagnosis of infected necrotizing...
Article
A 12-month implantable loop recorder detects more atrial fibrillation than 30-day external monitoring after ischemic stroke
January 7, 2022
Dr. Winget Clinical question: In patients with recent ischemic stroke, does monitoring for 12 months with an implantable loop recorder (ILR) detect more atrial fibrillation (AF) than 30 days with...
Article
No difference in outcomes comparing the treatment of cardiogenic shock with dobutamine versus milrinone
January 7, 2022
Dr. Winget Clinical question: Is there a benefit to selecting milrinone over dobutamine for inotropic support in patients with cardiogenic shock? Background: Inotropes, particularly milrinone...
Article
The hidden pandemic
January 7, 2022
Dr. Sekaran In the eyes of Anand Sekaran, MD, division head of hospital medicine, and medical director of inpatient services at Connecticut Children’s Medical Center in Hartford, Conn., it’s...
Article
A different kind of leadership rounds
January 7, 2022
In the early 2000s, the Institute for Healthcare Improvement helped popularize the idea of Leadership WalkRounds, encouraging health care leaders to regularly visit frontline clinical units to hear...