Devin Horton, MD
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Antibiotic Therapy, Appendectomy for Uncomplicated Acute Appendicitis
October 6, 2015
Clinical question: Is antibiotic therapy noninferior to appendectomy for treatment of uncomplicated acute appendicitis? Background: Previous randomized clinical trials have compared antibiotic therapy versus appendectomy for the treatment of uncomplicated, acute appendicitis.
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Social, System Factors Can Influence Decisions to Continue Patient Care
October 6, 2015
Clinical question: Why do healthcare providers work while sick? Background: Healthcare providers generally are aware of the risks of infection to hospitalized patients; however, despite this knowledge, several studies have revealed providers continue to work while ill. Study design: Mixed-meth
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Corticosteroids Show Benefit in Community-Acquired Pneumonia
August 25, 2015
Clinical question: Does corticosteroid treatment shorten systemic illness in patients admitted to the hospital for community-acquired pneumonia (CAP)? Background: Pneumonia is the third-leading cause of death worldwide.
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Clinical Variables Predict Debridement Failure in Septic Arthritis
July 29, 2015
Clinical question: What risk factors predict septic arthritis surgical debridement failure? Background: Standard treatment of septic arthritis is debridement and antibiotics. Unfortunately, 23%-48% of patients fail single debridement.
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Prednisolone or Pentoxifylline Show No Mortality Benefit in Alcoholic Hepatitis
July 29, 2015
Clinical question: Does administration of prednisolone or pentoxifylline reduce mortality in patients hospitalized with severe alcoholic hepatitis? Background: Alcoholic hepatitis is associated with high mortality.
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Corticosteroids Show Benefit in Community-Acquired Pneumonia
July 29, 2015
Joshua LaBrin, MD, SFHM, Kencee Graves, MD, Karli Edholm, MD, Devin Horton, MD, and Katie Lappe, MD; Division of General Internal Medicine, University of Utah School of Medicine, Salt Lake City
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Nomogram Predicts Post-Operative Readmission
July 29, 2015
Clinical question: Can a nomogram accurately predict a patient’s risk of post-operative 30-day readmission? Background: Medicare and Medicaid have implemented penalties for hospitals with high readmission rates.
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Antiepileptic Drugs Reduce Risk of Recurrent Unprovoked Seizures
July 29, 2015
Clinical question: What are the updated recommendations for treating first unprovoked seizure in adults? Background: Approximately 150,000 adults present with an unprovoked first seizure in the U.S. annually, and these events are associated with physical and psychological trauma.
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PPI Usage with SBP Prophylaxis Predicts Recurrent Infections in Cirrhosis
July 29, 2015
Clinical question: What are the risk factors for development of a recurrent infection in cirrhotic patients hospitalized with an initial infection? Background: Infections are a major cause of morbidity and mortality in patients with cirrhosis.
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Nontoxigenic C. diff Spores May Decrease Rates of Recurrent CDI
July 29, 2015
Clinical question: Is treatment with nontoxigenic C. diff strain M-3 (NTCD-M3) safe and effective in preventing recurrent Clostridium difficile infection (CDI)? Background: C. diff is the most commonly identified healthcare pathogen, and CDI has a 25%-30% recurrence rate. Not all C.