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Revision total joint replacements linked to higher infection risk
The 90-day risk of surgical site infection was 5.77 times higher after revision vs. primary total joint replacement.
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TEG-guided topped conventional transfusion in cirrhotic patients with variceal bleeding
With TEG, only four (13.3%) patients received transfusions, compared with every patient in the conventional transfusion group (P less...
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Zoster vaccination is underused but looks effective in IBD
For men with inflammatory bowel disease, herpes zoster vaccination was associated with about a 46% decrease in risk of associated infection...
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BMI in male teens predicts cardiomyopathy risk
The hazard ratio for dilated cardiomyopathy in adulthood was 1.38 when adolescent body mass index was 22.5-25.0 kg/m2 – and rose to 8....
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Pancreatic cancers often contained targetable mutations
A total of 17% of specimens harbored mutations that are potentially targetable with existing therapies. These mutations involved either RTK/ras/...
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Infections within first year of life predicted IBD
The correlation was strongest for onset by age 10 years.
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Induction trough levels predicted ustekinumab response in Crohn’s disease
An ustekinumab trough level of 2.0 mcg/mL or higher distinguished responders from nonresponders with an area under the receiver operating curve of...
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Clock gene disruption might underlie IBD
Multiple clock genes showed reduced mRNA expression in inflamed and uninflamed intestinal mucosa and peripheral white blood cells from patients,...
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AGA Clinical Practice Update: Direct-acting antivirals and hepatocellular carcinoma
For patients listed for liver transplantation, determine timing of DAA therapy on a case-by-case basis, consider regional wait times, availability...
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Ulipristal acetate tops placebo for uterine leiomyomas
Significantly greater improvements in physical and social activities were seen with both ulipristal doses, compared with placebo, from baseline to...
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Study compares tapering strategies in rheumatoid arthritis
Cumulative rates of flare at 1 year were 33% with initial tapering of conventional synthetic DMARDs and 43% with initial TNF-inhibitor tapering (...
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Induction trough levels predicted ustekinumab response in Crohn’s disease
An ustekinumab trough level of 2.0 mcg/mL or higher distinguished responders from nonresponders with an area under the receiver operating curve of...
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Tailoring the Mediterranean diet for NAFLD
Keys to success included providing recipes and meal planners, education on how lifestyle and diet contribute to NAFLD, and offering care in person...
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Positive psoriatic arthritis screens occur often in psoriasis patients
In all, 12.4% of patients had a positive screen for possibly undiagnosed psoriatic arthritis but had never been diagnosed with the disease.
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Gene therapy restored immunity in newly diagnosed SCID-X1
In the phase 1/2 study, seven infants had normal immune cells 3-4 months after treatment, while the eighth infant responded after a gene therapy...