Article
Should We Aim Higher? Actively Targeting High-Normal Potassium Levels Reduces Ventricular Arrhythmia Events and Hospitalizations in High-Risk Patients
- Vitaliy Rotenberg, MD, FACP
May 1, 2026
Clinical question: Does a treatment strategy targeting high-normal plasma potassium levels (4.5 to 5.0 mmol/L) reduce the risk of ventricular arrhythmias and cardiovascular events in high-risk...
Article
Antibiotic De-Escalation in Adults Hospitalized for Community- Onset Sepsis Without Evidence of Multidrug-Resistant Infection Is Safe
May 1, 2026
Clinical question: In patients hospitalized with community-onset sepsis, does empiric broad-spectrum antibiotic (BSA) de-escalation (on encounter day four), compared with continuation, affect...
Article
Response to Blood Culture Shortage Promotes High Value Care
May 1, 2026
Clinical question: Do diagnostic stewardship interventions in times of crisis lead to sustained change in blood-culture ordering practices? Background: It is estimated that a third of all blood...
Article
Liberal or Restrictive Postoperative Transfusion in Patients at High Cardiac Risk: The TOP Randomized Clinical Trial
May 1, 2026
Clinical question: Does a liberal transfusion strategy decrease the risk of death or major ischemic events after major surgical operations in patients at high risk of cardiac events? Background:...
Article
Predicting Contrast-Associated AKI
May 1, 2026
Clinical question: Do newer prediction models pooled in a systematic review predict contrast-associated acute kidney injury (CA-AKI)? Background: This systematic review updates a previous evaluation...
Article
Using Biomarkers to Guide Antibiotic Duration in Suspected Sepsis
May 1, 2026
Clinical question: Can using daily biomarker-guided protocols, procalcitonin (PCT), or C-reactive protein (CRP) to guide antibiotic duration in adults hospitalized with sepsis safely reduce...
Article
Sodium Bicarbonate Does Not Reduce 90-Day Mortality in Severe Metabolic Acidemia with AKI
May 1, 2026
Clinical question: In critically ill adults with severe metabolic acidemia and moderate to severe acute kidney injury (AKI), does intravenous sodium bicarbonate reduce 90-day all-cause...
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Article
The Value of Investing in Good Onboarding for Hospitalists
May 1, 2026
Every hospital system faces the challenges of orienting and integrating new healthcare personnel, including new hospitalists, many of whom come straight from residency or fellowship. Some bumps are...
Article
Effect of Hydrocortisone on Mortality in Patients with Severe CAP: The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial
April 9, 2026
NYU Langone Health Med-Lit Review Clinical Question: In adults admitted to intensive care with severe community-acquired pneumonia (CAP), does treatment with a seven-day course of intravenous...
Article
Aficamten Monotherapy is Superior to Metoprolol Monotherapy for Patients with Symptomatic Obstructive Hypertrophic Cardiomyopathy
April 9, 2026
NYU Langone Health Med-Lit Review Clinical Question: Is aficamten monotherapy superior to metoprolol monotherapy for patients with symptomatic obstructive hypertrophic cardiomyopathy? Background:...