Clinical Edge

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COVID-19 in pregnancy raises risk of preterm birth and severe disease

Key clinical point: Pregnant women with SARS-CoV-2 infections were more likely to have poor pregnancy outcomes and more severe disease.

Major finding: Rates of preterm birth were higher among women with confirmed SARS-CoV-2 infections compared with the national average (12.9% vs. 10.2%). Pregnant women with COVID-19 disease were significantly more likely than nonpregnant women to be admitted to intensive care (10.5 per 1,000 cases vs. 3.9 per 1,000 cases).

Study details: The data come from 4,442 pregnant women with COVID-19 and known pregnancy outcomes identified through the Surveillance for Emerging Threats to Mothers and Babies Network (SET-NET), and a second study of 23,434 pregnant women and 386,018 nonpregnant women aged 15-44 years with laboratory-confirmed COVID-19 infections identified through the National Notifiable Diseases Surveillance System (NNDSS).

Disclosures: The studies were supported by the Centers for Disease Control and Prevention. The researchers had no financial conflicts to disclose. Dr. Bianco had no financial conflicts to disclose.


Woodworth KR et al. MMWR. 2020 Nov 2. doi: 10.15585/mmwr.mm6944e2; Zambrano LD et al. MMWR. 2020 Nov 2. doi: 10.15585/mmwr.mm6944e3.