Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Immunotherapy, steroids had positive outcomes in COVID-19–associated multisystem inflammatory syndrome

Key clinical point: Multisystem inflammatory syndrome in children shares similarities with atypical Kawasaki disease, but prominent clinical signs are largely different.

Major finding: Left ventricular ejection fraction was less than 30% in 28% of patients, and 80% required inotropic support with 28% treated with ECMO.

Study details: A retrospective study of 35 children with acute heart failure potentially associated with SARS-CoV-2 infection and MIS-C.

Disclosures: The researchers reported having no financial disclosures.


Belhadjer Z et al. Circulation 2020 May 17. doi: 10.1161/circulationaha.120.048360.